JC virus induces a vigorous CD8+ cytotoxic T cell response in multiple sclerosis patients

Renaud A. Du Pasquier*, Marion C. Stein, Marco A. Lima, Xin Dang, Jims Jean-Jacques, Yue Zheng, Norman L. Letvin, Igor J. Koralnik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

We sought to compare the ongoing CD8+ cytotoxic T lymphocytes (CTL) immune response of MS patients to self and viral antigens. Using 51Cr release and tetramer staining assays, we found that the CTL response against VP1, the major capsid protein of the polyomavirus JC (JCV), was significantly higher than the one against epitopes of MBP and PLP. The JCV-specific CTL response was also significantly stronger in MS patients than healthy control subjects. These findings may shed a new light on the recent events related to the development of progressive multifocal leukoencephalopathy in three natalizumab-treated patients.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalJournal of Neuroimmunology
Volume176
Issue number1-2
DOIs
StatePublished - Jul 1 2006

Keywords

  • CD8T cells
  • JC virus
  • Multiple sclerosis
  • Myelin
  • Natalizumab
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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