JIL-1 kinase, a member of the male-specific lethal (MSL) complex, is necessary for proper dosage compensation of eye pigmentation in Drosophila

Stephanie Lerach, Weiguo Zhang, Huai Deng, Xiaomin Bao, Jack Girton, Jørgen Johansen, Kristen M. Johansen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The upregulation of the JIL-1 kinase on the male X chromosome and its association with the male-specific lethal (MSL) complex suggest that JIL-1 may play a role in regulating dosage compensation. To directly test this hypothesis we measured eye pigment levels of mutants in the X-linked white gene in an allelic series of JIL-1 hypomorphic mutants. We show that dosage compensation of wa alleles that normally do exhibit dosage compensation was severely impaired in the JIL-1 mutant backgrounds. As a control we also examined a hypomorphic white allele we that fails to dosage compensate in males due to a pogo element insertion. In this case the relative pigment level measured in males as compared to females remained approximately the same even in the most severe JIL-1 hypomorphic background. These results indicate that proper dosage compensation of eye pigment levels in males controlled by X-linked white alleles requires normal JIL-1 function.

Original languageEnglish (US)
Pages (from-to)213-215
Number of pages3
JournalGenesis
Volume43
Issue number4
DOIs
StatePublished - Dec 2005

Keywords

  • Dosage compensation
  • Drosophila
  • Eye pigmentation
  • JIL-1 kinase
  • MSL complex

ASJC Scopus subject areas

  • Genetics
  • Endocrinology
  • Cell Biology

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