John cunningham virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals

Raphael P. Viscidi*, Nina Khanna, Chen S. Tan, Xiuhung Li, Lisa Jacobson, David B. Clifford, Avindra Nath, Joseph B. Margolick, Keerti V. Shah, Hans H. Hirsch, Igor J. Koralnik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

We examined whether prediagnostic John Cunningham virus (JCV) antibodies and viremia are predictors of progressive multifocal leukoencephalopathy (PML) in 83 PML cases and 240 human immunodeficiency virus (HIV) disease-matched controls. JCV viremia was not predictive of PML, but some patients showed higher anti-JCV immunoglobulin G (IgG) responses 6 months prior to diagnosis.

Original languageEnglish (US)
Pages (from-to)711-715
Number of pages5
JournalClinical Infectious Diseases
Volume53
Issue number7
DOIs
StatePublished - Oct 1 2011

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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