Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies

Alan Menter, Joel M. Gelfand, Cody Connor, April W. Armstrong, Kelly M. Cordoro, Dawn M.R. Davis, Boni E. Elewski, Kenneth B. Gordon, Alice B. Gottlieb, Daniel H. Kaplan, Arthur Kavanaugh, Matthew Kiselica, Dario Kivelevitch, Neil J. Korman, Daniela Kroshinsky, Mark Lebwohl, Craig L. Leonardi, Jason Lichten, Henry W. Lim, Nehal N. MehtaAmy S. Paller, Sylvia L. Parra, Arun L. Pathy, Elizabeth Farley Prater, Robert S. Rahimi, Reena N. Rupani, Michael Siegel, Benjamin Stoff, Bruce E. Strober, Elliot B. Tapper, Emily B. Wong, Jashin J. Wu, Vidhya Hariharan*, Craig A. Elmets

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Psoriasis is a chronic inflammatory disease involving multiple organ systems and affecting approximately 2% of the world's population. In this guideline, we focus the discussion on systemic, nonbiologic medications for the treatment of this disease. We provide detailed discussion of efficacy and safety for the most commonly used medications, including methotrexate, cyclosporine, and acitretin, and provide recommendations to assist prescribers in initiating and managing patients on these treatments. Additionally, we discuss newer therapies, including tofacitinib and apremilast, and briefly touch on a number of other medications, including fumaric acid esters (used outside the United States) and therapies that are no longer widely used for the treatment of psoriasis (ie, hydroxyurea, leflunomide, mycophenolate mofetil, thioguanine, and tacrolimus).

Original languageEnglish (US)
Pages (from-to)1445-1486
Number of pages42
JournalJournal of the American Academy of Dermatology
Volume82
Issue number6
DOIs
StatePublished - Jun 2020

Keywords

  • Clinical guidelines for psoriasis
  • dermatology
  • nonbiologic systemic
  • psoriasis
  • psoriasis guidelines
  • skin disease

ASJC Scopus subject areas

  • Dermatology

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