Juvenile dermatomyositis: Immunogenetics, pathophysiology, and disease expression

Lauren M. Pachman*

*Corresponding author for this work

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

Data are rapidly accumulating documenting disease susceptibility may be linked to genetic markers (DQA1*0501 or related alleles) which are associated with upregulation of IFN-α/β inducible genes elicited in response to an antigen which may be viral. Continued immune-mediated inflammation, resulting in partial lipodystrophy and pathological calcifications, may be fanned by the increased production of TNFα usually associated with the TNFα-308A allele.

Original languageEnglish (US)
Pages (from-to)579-602
Number of pages24
JournalRheumatic Disease Clinics of North America
Volume28
Issue number3
DOIs
StatePublished - Aug 2002

ASJC Scopus subject areas

  • Rheumatology

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