Juvenile dermatomyositis (JDMS): New clues to diagnosis and pathogenesis

L. M. Pachman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The localization of focal inflammatory myopathy (IM) is aided by MRI, which facilitates diagnostic testing (muscle biopsy or EMG). Antibodies to antigens involved in protein synthesis are specific for IM and characterize distinct subsets of adult IM, but are rare in pediatric IM. In definite juvenile dermatomyositis, serological indicators of disease activity include neopterin and von Willebrand factor antigen, markers of macrophage activation, and endothelial cell damage, respectively; nailfold capillarioscopy documents small blood vessel involvement. Monitoring the percentage of circulating B cells may indicate the response to therapy.

Original languageEnglish (US)
Pages (from-to)S69-S73
JournalClinical and experimental rheumatology
Volume12
Issue numberSUPPL. 10
StatePublished - 1994

Keywords

  • MRI
  • antibody
  • juvenile dermatomyositis
  • myositis specific antibody
  • nailfold capillarioscopy
  • neopterin
  • von Willebrand Factor antigen

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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