K-t GRAPPA-accelerated 4D flow MRI of liver hemodynamics: influence of different acceleration factors on qualitative and quantitative assessment of blood flow

Zoran Stankovic*, Jury Fink, Jeremy D. Collins, Edouard Semaan, Maximilian F. Russe, James C. Carr, Michael Markl, Mathias Langer, Bernd Jung

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Materials and methods: k-t GRAPPA accelerated 4D flow MRI of the liver vasculature was evaluated in 16 healthy volunteers at 3T with acceleration factors R = 3, R = 5, and R = 8 (2.0 × 2.5 × 2.4 mm3, TR = 82 ms), and R = 5 (TR = 41 ms); GRAPPA R = 2 was used as the reference standard. Qualitative flow analysis included grading of 3D streamlines and time-resolved particle traces. Quantitative evaluation assessed velocities, net flow, and wall shear stress (WSS).

Results: Significant scan time savings were realized for all acceleration factors compared to standard GRAPPA R = 2 (21–71 %) (p < 0.001). Quantification of velocities and net flow offered similar results between k-t GRAPPA R = 3 and R = 5 compared to standard GRAPPA R = 2. Significantly increased leakage artifacts and noise were seen between standard GRAPPA R = 2 and k-t GRAPPA R = 8 (p < 0.001) with significant underestimation of peak velocities and WSS of up to 31 % in the hepatic arterial system (p <0.05). WSS was significantly underestimated up to 13 % in all vessels of the portal venous system for k-t GRAPPA R = 5, while significantly higher values were observed for the same acceleration with higher temporal resolution in two veins (p < 0.05).

Conclusion: k-t acceleration of 4D flow MRI is feasible for liver hemodynamic assessment with acceleration factors R = 3 and R = 5 resulting in a scan time reduction of at least 40 % with similar quantitation of liver hemodynamics compared with GRAPPA R = 2.

Objective: We sought to evaluate the feasibility of k-t parallel imaging for accelerated 4D flow MRI in the hepatic vascular system by investigating the impact of different acceleration factors.

Original languageEnglish (US)
Pages (from-to)149-159
Number of pages11
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume28
Issue number2
DOIs
StatePublished - Apr 1 2015

Keywords

  • 4D flow MRI
  • Liver hemodynamics
  • Quantification
  • Wall shear stress
  • k-t GRAPPA

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'K-t GRAPPA-accelerated 4D flow MRI of liver hemodynamics: influence of different acceleration factors on qualitative and quantitative assessment of blood flow'. Together they form a unique fingerprint.

  • Cite this