TY - JOUR
T1 - Kainate receptors coming of age
T2 - Milestones of two decades of research
AU - Contractor, Anis
AU - Mulle, Christophe
AU - Swanson, Geoffrey T.
N1 - Funding Information:
Preparation of this review was supported by grants from the National Institutes of Health/National Institute of Neurological Disorders and Stroke (R01NS058894 to A.C. and R01NS044322 to G.T.S.) and from the CNRS (to C.M.).
PY - 2011/3
Y1 - 2011/3
N2 - Two decades have passed since the first report of the cloning of a kainate-type glutamate receptor (KAR) subunit. The intervening years have seen a rapid growth in our understanding of the biophysical properties and function of KARs in the brain. This research has led to an appreciation that KARs play very distinct roles at synapses relative to other members of the glutamate-gated ion channel receptor family, despite structural and functional commonalities. The surprisingly diverse and complex nature of KAR signaling underlies their unique impact upon neuronal networks through their direct and indirect effects on synaptic transmission, and their prominent role in regulating cell excitability. This review pieces together highlights from the two decades of research subsequent to the cloning of the first subunit, and provides an overview of our current understanding of the role of KARs in the CNS and their potential importance to neurological and neuropsychiatric disorders.
AB - Two decades have passed since the first report of the cloning of a kainate-type glutamate receptor (KAR) subunit. The intervening years have seen a rapid growth in our understanding of the biophysical properties and function of KARs in the brain. This research has led to an appreciation that KARs play very distinct roles at synapses relative to other members of the glutamate-gated ion channel receptor family, despite structural and functional commonalities. The surprisingly diverse and complex nature of KAR signaling underlies their unique impact upon neuronal networks through their direct and indirect effects on synaptic transmission, and their prominent role in regulating cell excitability. This review pieces together highlights from the two decades of research subsequent to the cloning of the first subunit, and provides an overview of our current understanding of the role of KARs in the CNS and their potential importance to neurological and neuropsychiatric disorders.
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U2 - 10.1016/j.tins.2010.12.002
DO - 10.1016/j.tins.2010.12.002
M3 - Review article
C2 - 21256604
AN - SCOPUS:79952245139
SN - 0378-5912
VL - 34
SP - 154
EP - 163
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 3
ER -