Kainate receptors regulate the functional properties of young adult-born dentate granule cells

Yiwen Zhu, John N. Armstrong, Anis Contractor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Both inhibitory and excitatory neurotransmitter receptors can influence maturation and survival of adult-born neurons in the dentate gyrus; nevertheless, how these two neurotransmitter systems affect integration of new neurons into the existing circuitry is still not fully characterized. Here, we demonstrate that glutamate receptors of the kainate receptor (KAR) subfamily are expressed in adult-born dentate granule cells (abDGCs) and that, through their interaction with GABAergic signaling mechanisms, they alter the functional properties of adult-born cells during a critical period of their development. Both the intrinsic properties and synaptic connectivity of young abDGCs were affected. Timed KAR loss in a cohort of young adult-born neurons in mice disrupted their performance in a spatial discrimination task but not in a hippocampal-dependent fear conditioning task. Together, these results demonstrate the importance of KARs in the proper functional development of young abDGCs.

Original languageEnglish (US)
Article number109751
JournalCell reports
Volume36
Issue number12
DOIs
StatePublished - Sep 21 2021

Keywords

  • E
  • GABA
  • adult-born granule cell
  • hippocampus
  • kainate receptor
  • neurogenesis
  • object location memory

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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