Kainate receptors: Subunits, synaptic localization and function

Ramesh Chittajallu*, Steven P. Braithwaite, Vernon R.J. Clarke, Jeremy M. Henley

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

227 Scopus citations

Abstract

Although it is well established that kainate receptors constitute an entirely separate group of proteins from AMPA receptors, their physiological functions remain unclear. The molecular cloning of subunits that form kainate receptors and the ability to study recombinant receptors is leading to an increased understanding of their functional properties. Furthermore, the development of kainate receptor-selective agonists and antagonists over the past few years is now allowing the physiological roles of these receptors and, in some cases, specific subunits to be investigated. As a consequence, the synaptic activation of postsynaptic kainate receptors and the presence of presynaptic kainate receptors that serve to regulate excitatory and inhibitory synaptic transmission have been described.

Original languageEnglish (US)
Pages (from-to)26-35
Number of pages10
JournalTrends in Pharmacological Sciences
Volume20
Issue number1
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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