Kainic acid induction of mossy fiber sprouting: Dependence on mouse strain

Isabel Cantallops*, Aryeh Routtenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


After seizures caused by kindling or kainic acid (KA), hippocampal granule-cell axons, the mossy fibers, sprout into the supragranular layer of the rat. The mechanisms underlying this phenomenon remain elusive, but excitotoxic loss of hilar cells, which project to this supragranular layer, is suspected to be a critical determinant. Consistent with this hypothesis, we previously reported that while rats show mossy fiber sprouting after kainate, ICR mice do not. This may be associated with the observation that ICR mice, unlike rats, do not appear to show hilar cell death after KA. Other strains of mice, however, such as 129/SvEMS, do show hilar cell death after KA. We examined the possibility that the 129/SvEMS mouse strain would show granule-cell sprouting, in contrast to ICR mice. After administration of KA, mossy fiber sprouting was indeed observed in strain 129/SvEMS, but only in animals displaying evident hilar cell death. In contrast, neither hilar cell death nor mossy fiber sprouting was observed in ICR mice, confirming previous results. Both mouse strains demonstrated comparable behavioral seizures. These results strengthen the view that hilar cell death, together with epileptogenesis, triggers reactive synaptogenesis and mossy fiber sprouting. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)269-273
Number of pages5
Issue number3
StatePublished - Jul 18 2000


  • 129SvEMS
  • ICR
  • Plasticity
  • Reactive synaptogenesis
  • Seizures

ASJC Scopus subject areas

  • Neuroscience(all)


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