Kainic acid lesions enhance locomotor responses to novelty, saline, amphetamine, and MK-801

Mark E. Bardgett*, Pamela S. Jacobs, Jamie L. Jackson, John G. Csernansky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Intracerebroventricular (i.c.v.) administration of kainic acid (KA) to rats produces neuronal loss in the hippocampus and other areas of the limbic system. The present study demonstrates that i.c.v. KA enhances the locomotor response to novelty and saline injection, as well as to amphetamine and MK-801. Sixteen to 18 days after i.c.v. administration of KA or vehicle, lesioned and control rats were placed in a novel cage, and locomotor activity and grooming were recorded for 30 min prior to and 60 min following a subcutaneous injection of saline, D-amphetamine, or MK-801. In response to the novel cage and after each injection, KA rats exhibited increased locomotor activity relative to controls. Grooming behavior was found to be elevated in the KA rats when compared to controls, but only in response to the novel cage and saline injection. The possibility that damage to the limbic system disrupts dopaminergic regulation of locomotor behavior is discussed, as well as implications for neuropathology in schizophrenia.

Original languageEnglish (US)
Pages (from-to)47-55
Number of pages9
JournalBehavioural Brain Research
Volume84
Issue number1-2
DOIs
StatePublished - Mar 1997

Keywords

  • NMDA
  • dopamine
  • glutamate
  • grooming
  • hippocampus
  • kainic acid
  • mesolimbic
  • nucleus accumbens
  • schizophrenia

ASJC Scopus subject areas

  • Behavioral Neuroscience

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