Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers

Zhong Xie, Lauren P. Shapiro, Michael E. Cahill, Theron A. Russell, Pascale N. Lacor, William L. Klein, Peter Penzes*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Synapse degeneration and dendritic spine dysgenesis are believed to be crucial early steps in Alzheimer's disease (AD), and correlate with cognitive deficits in AD patients. Soluble amyloid beta (Aβ)-derived oligomers, also termed Aβ-derived diffusible ligands (ADDLs), accumulate in the brain of AD patients and play a crucial role in AD pathogenesis. ADDLs bind to mature hippocampal neurons, induce structural changes in dendritic spines and contribute to neuronal death. However, mechanisms underlying structural and toxic effects are not fully understood. Here, we report that ADDLs bind to cultured mature cortical pyramidal neurons and induce spine dysgenesis. ADDL treatment induced the rapid depletion of kalirin-7, a brain-specific guanine-nucleotide exchange factor for the small GTPase Rac1, from spines. Kalirin-7 is a key regulator of dendritic spine morphogenesis and maintenance in forebrain pyramidal neurons and here we show that overexpression of kalirin-7 prevents ADDL-induced spine degeneration. Taken together, our results suggest that kalirin-7 may play a role in the early events leading to synapse degeneration, and its pharmacological activation may prevent or delay synapse pathology in AD.

Original languageEnglish (US)
Pages (from-to)1091-1101
Number of pages11
JournalEuropean Journal of Neuroscience
Volume49
Issue number9
DOIs
StatePublished - May 2019

    Fingerprint

Keywords

  • Alzheimer's disease
  • Rac1
  • guanine-nucleotide exchange factors
  • synapse

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this