Kalirin signaling: Implications for synaptic pathology

Peter Penzes*, Christine Remmers

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Spine morphogenesis and plasticity are intimately linked to cognition, and there is strong evidence that aberrant regulation of spine plasticity is associated with physiological, behavioral, and pathological conditions. The neuronal guanine nucleotide exchange factor (GEF) kalirin is emerging as a key regulator of structural and functional plasticity at dendritic spines. Here, we review recent studies that have genetically and functionally linked kalirin signaling to a number of human disorders. Kalirin signaling may thus represent a disease mechanism and provide a novel therapeutic target.

Original languageEnglish (US)
Pages (from-to)109-118
Number of pages10
JournalMolecular Neurobiology
Volume45
Issue number1
DOIs
StatePublished - Feb 2012

Keywords

  • ADHD
  • Addiction
  • Alzheimer's disease
  • DISC1
  • Genetic
  • Glutamatergic
  • Mental disorder
  • NRG1
  • Postmortem
  • Schizophrenia
  • Stroke
  • erbB4

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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