KAP-1, a novel corepressor for the highly conserved KRAB repression domain

Josh R. Friedman, William J. Fredericks, David E. Jensen, David W. Speicher, Xiao Pei Huang, Eric G. Neilson, Frank J. Rauscher*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

538 Scopus citations


The KRAB repression domain is one of the most widely distributed transcriptional effector domains yet identified, but its mechanism of repression is unknown. We have cloned a corepressor, KAP-1, which associates with the KRAB domain but not with KRAB mutants that have lost repression activity. KAP-1 can enhance KRAB-mediated repression and is a repressor when directly tethered to DNA. KAP-1 contains a RING finger, B boxes, and a PHD finger; the RING-B1-B2 structure is required for KRAB binding and corepression. We propose that KAP-1 may be a universal corepressor for the large family of KRAB domain-containing transcription factors.

Original languageEnglish (US)
Pages (from-to)2067-2078
Number of pages12
JournalGenes and Development
Issue number16
StatePublished - 1996


  • Corepressor
  • KRAB domain
  • RING finger
  • zinc-finger

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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