Abstract
Integration of reverse transcribed HIV-1 DNA into the host genome, catalyzed by HIV-1 integrase, represents an obligate step in establishing productive viral infection. Allouch et al. (2011) identify KAP1 (TRIM28) as an interaction partner of acetylated integrase. KAP1, in complex with HDAC1, represses HIV-1 integration through specific deacetylation of HIV-1 integrase.
Original language | English (US) |
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Pages (from-to) | 447-448 |
Number of pages | 2 |
Journal | Cell Host and Microbe |
Volume | 9 |
Issue number | 6 |
DOIs | |
State | Published - Jun 16 2011 |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Virology