KAPs off for HIV-1 integration

Anna Figueiredo; Thomas J. Hope

doi:10.1016/j.chom.2011.05.009

KAPs off for HIV-1 integration

Anna Figueiredo, Thomas J. Hope

Cell & Developmental Biology

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Integration of reverse transcribed HIV-1 DNA into the host genome, catalyzed by HIV-1 integrase, represents an obligate step in establishing productive viral infection. Allouch et al. (2011) identify KAP1 (TRIM28) as an interaction partner of acetylated integrase. KAP1, in complex with HDAC1, represses HIV-1 integration through specific deacetylation of HIV-1 integrase.

Original language	English (US)
Pages (from-to)	447-448
Number of pages	2
Journal	Cell Host and Microbe
Volume	9
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2011.05.009
State	Published - Jun 16 2011

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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title = "KAPs off for HIV-1 integration",

abstract = "Integration of reverse transcribed HIV-1 DNA into the host genome, catalyzed by HIV-1 integrase, represents an obligate step in establishing productive viral infection. Allouch et al. (2011) identify KAP1 (TRIM28) as an interaction partner of acetylated integrase. KAP1, in complex with HDAC1, represses HIV-1 integration through specific deacetylation of HIV-1 integrase.",

author = "Anna Figueiredo and Hope, {Thomas J.}",

note = "Funding Information: A.F. and T.J.H. are supported by NIH grants (P50-GM082545 and RO1 A1047770).",

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AU - Figueiredo, Anna

AU - Hope, Thomas J.

N1 - Funding Information: A.F. and T.J.H. are supported by NIH grants (P50-GM082545 and RO1 A1047770).

PY - 2011/6/16

Y1 - 2011/6/16

N2 - Integration of reverse transcribed HIV-1 DNA into the host genome, catalyzed by HIV-1 integrase, represents an obligate step in establishing productive viral infection. Allouch et al. (2011) identify KAP1 (TRIM28) as an interaction partner of acetylated integrase. KAP1, in complex with HDAC1, represses HIV-1 integration through specific deacetylation of HIV-1 integrase.

AB - Integration of reverse transcribed HIV-1 DNA into the host genome, catalyzed by HIV-1 integrase, represents an obligate step in establishing productive viral infection. Allouch et al. (2011) identify KAP1 (TRIM28) as an interaction partner of acetylated integrase. KAP1, in complex with HDAC1, represses HIV-1 integration through specific deacetylation of HIV-1 integrase.

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DO - 10.1016/j.chom.2011.05.009

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JF - Cell Host and Microbe

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