KAPs off for HIV-1 integration

Anna Figueiredo, Thomas J. Hope

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations

Abstract

Integration of reverse transcribed HIV-1 DNA into the host genome, catalyzed by HIV-1 integrase, represents an obligate step in establishing productive viral infection. Allouch et al. (2011) identify KAP1 (TRIM28) as an interaction partner of acetylated integrase. KAP1, in complex with HDAC1, represses HIV-1 integration through specific deacetylation of HIV-1 integrase.

Original languageEnglish (US)
Pages (from-to)447-448
Number of pages2
JournalCell Host and Microbe
Volume9
Issue number6
DOIs
StatePublished - Jun 16 2011

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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