Kawasaki disease and immunisation: A systematic review

Linny Kimly Phuong, Caterina Bonetto, Jim Buttery, Yolanda Brauchli Pernus, Rebecca Chandler, Patrizia Felicetti, Karen L. Goldenthal, Merita Kucuku, Giuseppe Monaco, Barbara Pahud, Stanford T. Shulman, Karina A. Top, Francesco Trotta, Rolando Ulloa-Gutierrez, Frederick Varricchio, Sarah de Ferranti, Jane W. Newburger, Nagib Dahdah, Surjit Singh, Jan Bonhoeffer*David Burgner, The Brighton Collaboration Kawasaki Disease (KD) Working Group

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background Kawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation. Methods We conducted a systematic literature review using various reference sources to review the available evidence published in the literature. Results We identified twenty seven publications reporting a temporal association between immunisation and Kawasaki disease. We present a systematic review of data drawn from randomised controlled trials, observational studies, case series and reports, and reviews. Overall there was a lack of standardised case definitions, making data interpretation and comparability challenging. Conclusions Although a temporal relationship between immunisation and Kawasaki disease is suggested, evidence for an increased risk or a causal association is lacking. Implementation of a standardised Kawasaki disease case definition would increase confidence in the findings and add value to future studies of pre- or post-licensure vaccine safety studies.

Original languageEnglish (US)
Pages (from-to)1770-1779
Number of pages10
JournalVaccine
Volume35
Issue number14
DOIs
StatePublished - Mar 27 2017

Keywords

  • Adverse event
  • Case definition
  • Guidelines
  • Immunisation
  • Kawasaki disease
  • Systematic review

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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