KCTD11 tumor suppressor gene expression is reduced in prostate adenocarcinoma

Francesca Zazzeroni*, Daniela Nicosia, Alessandra Tessitore, Rita Gallo, Daniela Verzella, Mariafausta Fischietti, Davide Vecchiotti, Luca Ventura, Daria Capece, Alberto Gulino, Edoardo Alesse

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Prostate cancer is the most common noncutaneous cancer among men in the United States. A genetic contribution to prostate cancer risk has been documented, but knowledge of the molecular mechanisms involved in prostate cancer initiation is still not well understood. Loss of heterozygosity (LOH) of chromosomal regions is crucial in tumor progression. In human prostate cancer, several chromosomal regions demonstrating a high frequency of LOH have been previously identified. KCTD11 (REN) is a tumor suppressor gene mapping on human chromosome 17p13.2, whose expression is frequently lost in human medulloblastoma and in several other cancer types. KCTD11 acts as a negative regulator of the Hedgehog (Hh) signaling. Here, we demonstrated that KCTD11 LOH is a common genetic lesion in human prostate adenocarcinoma. Indeed, nuclear KCTD11 protein expression is strongly reduced in primary prostate cancer, and this event correlated with overexpression of proteins acting into the Hedgehog pathway. Low levels of KCTD11 mRNA have been also observed in prostatic cancer cells, and ectopic overexpression of KCTD11 led to growth arrest. Our study demonstrates and supports that KCTD11, as well as negatively regulated downstream effectors belonging to Hh signaling, plays a role in prostate cancer pathogenesis. This could be suitable to characterize new diagnostic and therapeutic markers.

Original languageEnglish (US)
Article number380398
JournalBioMed Research International
StatePublished - 2014

ASJC Scopus subject areas

  • General Immunology and Microbiology
  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'KCTD11 tumor suppressor gene expression is reduced in prostate adenocarcinoma'. Together they form a unique fingerprint.

Cite this