Keloids: Prevention and Management

Douglas M. Sidle; Haena Kim

doi:10.1016/j.fsc.2011.06.005

Keloids: Prevention and Management

Douglas M. Sidle^*, Haena Kim

^*Corresponding author for this work

Otolaryngology

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Keloids result from an abnormal wound-healing process in which the normal regulatory pathways during tissue regeneration and scar remodeling are disrupted. While the pathogenesis of keloids continues to be investigated, numerous treatment options exist. Although prevention of keloid formation is the best management, early recognition of keloid formation is integral in treatment and prevention of recurrence. Surgical resection with adjuvant silicone gel sheeting or triamcinolone injection is common, but can still result in recurrence. New treatments include chemotherapeutics such as 5-fluorouracil, bleomycin, and mitomycin C. Although further clinical investigation is required for newer treatments, initial results are promising.

Original language	English (US)
Pages (from-to)	505-515
Number of pages	11
Journal	Facial plastic surgery clinics of North America
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/j.fsc.2011.06.005
State	Published - Aug 2011

Keywords

Hypertrophic scars
Keloid
Keloid pathophysiology
Scar management
Wound healing

ASJC Scopus subject areas

Surgery

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10.1016/j.fsc.2011.06.005

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abstract = "Keloids result from an abnormal wound-healing process in which the normal regulatory pathways during tissue regeneration and scar remodeling are disrupted. While the pathogenesis of keloids continues to be investigated, numerous treatment options exist. Although prevention of keloid formation is the best management, early recognition of keloid formation is integral in treatment and prevention of recurrence. Surgical resection with adjuvant silicone gel sheeting or triamcinolone injection is common, but can still result in recurrence. New treatments include chemotherapeutics such as 5-fluorouracil, bleomycin, and mitomycin C. Although further clinical investigation is required for newer treatments, initial results are promising.",

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AB - Keloids result from an abnormal wound-healing process in which the normal regulatory pathways during tissue regeneration and scar remodeling are disrupted. While the pathogenesis of keloids continues to be investigated, numerous treatment options exist. Although prevention of keloid formation is the best management, early recognition of keloid formation is integral in treatment and prevention of recurrence. Surgical resection with adjuvant silicone gel sheeting or triamcinolone injection is common, but can still result in recurrence. New treatments include chemotherapeutics such as 5-fluorouracil, bleomycin, and mitomycin C. Although further clinical investigation is required for newer treatments, initial results are promising.

KW - Hypertrophic scars

KW - Keloid

KW - Keloid pathophysiology

KW - Scar management

KW - Wound healing

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Keloids: Prevention and Management

Abstract

Keywords

ASJC Scopus subject areas

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