Keratinocyte survival, differentiation, and death: Many roads lead to mitogen-activated protein kinase

Richard L. Eckert; Tatiana Efimova; Shervin R. Dashti; Sivaprakasam Balasubramanian; Anne Deucher; James F. Crish; Michael Sturniolo; Frederic Bone

doi:10.1046/j.1523-1747.2002.19634.x

Keratinocyte survival, differentiation, and death: Many roads lead to mitogen-activated protein kinase

Richard L. Eckert^*, Tatiana Efimova, Shervin R. Dashti, Sivaprakasam Balasubramanian, Anne Deucher, James F. Crish, Michael Sturniolo, Frederic Bone

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

The epidermis is a dynamic and continually renewing surface that provides and maintains a life-sustaining interface with the environment. The epidermal keratinocyte, the major cell type of the epidermis, undergoes a complex and carefully choreographed program of differentiation. This process requires a balance between keratinocyte proliferation, differentiation, and apoptosis. This overview will concentrate on cascades that regulate the balance between keratinocyte cell proliferation and survival, and apoptosis and cell differentiation, with a particular emphasis on the role of the mitogen-activated protein kinase cascades. A summary of the literature suggests that extracellular regulated kinases function to promote keratinocyte proliferation and survival, whereas p38 mitogen-activated protein kinase functions to promote differentiation and apoptosis.

Original language	English (US)
Pages (from-to)	36-40
Number of pages	5
Journal	Journal of Investigative Dermatology Symposium Proceedings
Volume	7
Issue number	1
DOIs	https://doi.org/10.1046/j.1523-1747.2002.19634.x
State	Published - Dec 2002

Funding

This work utilized the facilities of the Skin Diseases Research Center of Northeast Ohio (NIH, AR39750) and was supported by grants from the National Institutes of Health (RLE). Dr. Efimova is a Dermatology Foundation Research Fellow, and Anne Deucher is a Medical Students Training Program Fellow.

Keywords

Apoptosis
Caspase
Epidermis
Gene expression
Keratinocyte differentiation
MAPK

ASJC Scopus subject areas

Dermatology
Molecular Biology
Biotechnology
Cell Biology

Access to Document

10.1046/j.1523-1747.2002.19634.x

Cite this

@article{88d5baf163f040c8965b3313d6700310,

title = "Keratinocyte survival, differentiation, and death: Many roads lead to mitogen-activated protein kinase",

abstract = "The epidermis is a dynamic and continually renewing surface that provides and maintains a life-sustaining interface with the environment. The epidermal keratinocyte, the major cell type of the epidermis, undergoes a complex and carefully choreographed program of differentiation. This process requires a balance between keratinocyte proliferation, differentiation, and apoptosis. This overview will concentrate on cascades that regulate the balance between keratinocyte cell proliferation and survival, and apoptosis and cell differentiation, with a particular emphasis on the role of the mitogen-activated protein kinase cascades. A summary of the literature suggests that extracellular regulated kinases function to promote keratinocyte proliferation and survival, whereas p38 mitogen-activated protein kinase functions to promote differentiation and apoptosis.",

keywords = "Apoptosis, Caspase, Epidermis, Gene expression, Keratinocyte differentiation, MAPK",

author = "Eckert, {Richard L.} and Tatiana Efimova and Dashti, {Shervin R.} and Sivaprakasam Balasubramanian and Anne Deucher and Crish, {James F.} and Michael Sturniolo and Frederic Bone",

note = "Funding Information: This work utilized the facilities of the Skin Diseases Research Center of Northeast Ohio (NIH, AR39750) and was supported by grants from the National Institutes of Health (RLE). Dr. Efimova is a Dermatology Foundation Research Fellow, and Anne Deucher is a Medical Students Training Program Fellow.",

year = "2002",

month = dec,

doi = "10.1046/j.1523-1747.2002.19634.x",

language = "English (US)",

volume = "7",

pages = "36--40",

journal = "Journal of Investigative Dermatology Symposium Proceedings",

issn = "1087-0024",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Keratinocyte survival, differentiation, and death

T2 - Many roads lead to mitogen-activated protein kinase

AU - Eckert, Richard L.

AU - Efimova, Tatiana

AU - Dashti, Shervin R.

AU - Balasubramanian, Sivaprakasam

AU - Deucher, Anne

AU - Crish, James F.

AU - Sturniolo, Michael

AU - Bone, Frederic

N1 - Funding Information: This work utilized the facilities of the Skin Diseases Research Center of Northeast Ohio (NIH, AR39750) and was supported by grants from the National Institutes of Health (RLE). Dr. Efimova is a Dermatology Foundation Research Fellow, and Anne Deucher is a Medical Students Training Program Fellow.

PY - 2002/12

Y1 - 2002/12

N2 - The epidermis is a dynamic and continually renewing surface that provides and maintains a life-sustaining interface with the environment. The epidermal keratinocyte, the major cell type of the epidermis, undergoes a complex and carefully choreographed program of differentiation. This process requires a balance between keratinocyte proliferation, differentiation, and apoptosis. This overview will concentrate on cascades that regulate the balance between keratinocyte cell proliferation and survival, and apoptosis and cell differentiation, with a particular emphasis on the role of the mitogen-activated protein kinase cascades. A summary of the literature suggests that extracellular regulated kinases function to promote keratinocyte proliferation and survival, whereas p38 mitogen-activated protein kinase functions to promote differentiation and apoptosis.

AB - The epidermis is a dynamic and continually renewing surface that provides and maintains a life-sustaining interface with the environment. The epidermal keratinocyte, the major cell type of the epidermis, undergoes a complex and carefully choreographed program of differentiation. This process requires a balance between keratinocyte proliferation, differentiation, and apoptosis. This overview will concentrate on cascades that regulate the balance between keratinocyte cell proliferation and survival, and apoptosis and cell differentiation, with a particular emphasis on the role of the mitogen-activated protein kinase cascades. A summary of the literature suggests that extracellular regulated kinases function to promote keratinocyte proliferation and survival, whereas p38 mitogen-activated protein kinase functions to promote differentiation and apoptosis.

KW - Apoptosis

KW - Caspase

KW - Epidermis

KW - Gene expression

KW - Keratinocyte differentiation

KW - MAPK

UR - http://www.scopus.com/inward/record.url?scp=0036967298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036967298&partnerID=8YFLogxK

U2 - 10.1046/j.1523-1747.2002.19634.x

DO - 10.1046/j.1523-1747.2002.19634.x

M3 - Article

C2 - 12518790

AN - SCOPUS:0036967298

SN - 1087-0024

VL - 7

SP - 36

EP - 40

JO - Journal of Investigative Dermatology Symposium Proceedings

JF - Journal of Investigative Dermatology Symposium Proceedings

IS - 1

ER -

Keratinocyte survival, differentiation, and death: Many roads lead to mitogen-activated protein kinase

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this