Ketorolac does not reduce effectiveness of pleurodesis in pediatric patients with spontaneous pneumothorax

Radhames E. Lizardo*, Simone Langness, Katherine P. Davenport, Karen Kling, Timothy Fairbanks, Stephen W. Bickler, Julia Grabowski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Purpose Antiinflammatory medications are thought to reduce the effectiveness of pleurodesis performed for the treatment of spontaneous pneumothorax. We reviewed our experience with children undergoing video-assisted thorascopic surgery (VATS) with pleurodesis for pneumothorax to determine if ketorolac administration influences patient outcomes. Methods A retrospective review of patients who underwent VATS pleurodesis for spontaneous pneumothorax from 2009 to 2013 at a pediatric hospital was performed. Length of stay, radiographic pneumothorax resolution prior to discharge, and ipsilateral recurrence rates were compared in patients who did and did not receive perioperative ketorolac. Results Over a 50-month period, 51 patients underwent VATS with mechanical pleurodesis for spontaneous pneumothorax. The average age was 15.5 years, and 76% were male. Ketorolac was administered to 26/51 patients. There were no differences in average length of stay (11.3 vs 10.9 days, p = 0.36), incidence of residual pneumothorax at discharge (22/41 vs 19/41, p = 0.48), or ipsilateral recurrence (5/10 vs 5/10, p = 1). Conclusions Despite the intrinsic antiinflammatory properties of ketorolac, our data suggests that its use for patients undergoing pleurodesis for spontaneous pneumothorax does not detrimentally influence the outcomes of surgery. Therefore, we conclude that ketorolac can be used for pain control in this population. Large-scale studies are warranted to validate these findings. Published by Elsevier Inc.

Original languageEnglish (US)
Pages (from-to)2035-2037
Number of pages3
JournalJournal of pediatric surgery
Issue number12
StatePublished - 2015


  • Children
  • Ketorolac
  • Outcomes
  • Pleurodesis
  • Pneumothorax
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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