Kicking off the polo game

Frank Eckerdt*, James L. Maller

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

15 Scopus citations


Polo-like kinase 1 (Plk1) is essential for checkpoint recovery and the activation of key mitotic enzymes; however, its own activation mechanism has remained elusive. Recent findings show that Bora, a G2-M expressed protein, facilitates Plk1 activation by the oncogenic kinase Aurora A in G2. During mitosis, Plk1-dependent Bora degradation promotes Aurora A localization to the centrosome and/or spindle. Bora-dependent regulation provides important new insights into interactions between key mitotic kinases.

Original languageEnglish (US)
Pages (from-to)511-513
Number of pages3
JournalTrends in Biochemical Sciences
Issue number11
StatePublished - Nov 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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