TY - JOUR
T1 - Kicking off the polo game
AU - Eckerdt, Frank
AU - Maller, James L.
PY - 2008/11
Y1 - 2008/11
N2 - Polo-like kinase 1 (Plk1) is essential for checkpoint recovery and the activation of key mitotic enzymes; however, its own activation mechanism has remained elusive. Recent findings show that Bora, a G2-M expressed protein, facilitates Plk1 activation by the oncogenic kinase Aurora A in G2. During mitosis, Plk1-dependent Bora degradation promotes Aurora A localization to the centrosome and/or spindle. Bora-dependent regulation provides important new insights into interactions between key mitotic kinases.
AB - Polo-like kinase 1 (Plk1) is essential for checkpoint recovery and the activation of key mitotic enzymes; however, its own activation mechanism has remained elusive. Recent findings show that Bora, a G2-M expressed protein, facilitates Plk1 activation by the oncogenic kinase Aurora A in G2. During mitosis, Plk1-dependent Bora degradation promotes Aurora A localization to the centrosome and/or spindle. Bora-dependent regulation provides important new insights into interactions between key mitotic kinases.
UR - http://www.scopus.com/inward/record.url?scp=54249103981&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54249103981&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2008.08.004
DO - 10.1016/j.tibs.2008.08.004
M3 - Short survey
C2 - 18818085
AN - SCOPUS:54249103981
SN - 0968-0004
VL - 33
SP - 511
EP - 513
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 11
ER -