Kidney transplantation in mice

Zheng Jenny Zhang*, Jiao Jing Wang, Xueqiong Wang, Jing Han

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Kidney transplantation is the treatment of choice for patients with end-stage renal failure. However, long-term function of the transplanted organ is commonly hindered by chronic allograft dysfunction (CAD). Mechanisms of CAD remain largely unknown.Investigations employing small animal models of kidney transplantation continue to be of paramount importance in enhancing our knowledge of transplant immunobiology,allowing for the design of therapeutic strategies to improve clinical outcomes. With enormous advances in molecular biology and genetic engineering over the past decade,murine models of kidney transplantation have become an increasingly powerful tool for understanding the biological processes of kidney allograft rejection at the molecular level, and for determining significant targets for effective interventions. However, kidney transplantation in mice is a highly challenging surgical procedure. Although techniques therein have been described for many years, few centers in the world have utilized this model due to its technical complexity. The technique of mouse kidney transplantation described in this chapter is based on more than 3000 successful kidney transplantations with a 90% survival rate; it has been used by investigators in multiple research centers around the world to explore novel molecular pathways involved in the immunological and physiological processes inherent in kidney transplantation.

Original languageEnglish (US)
Title of host publicationExperimental Organ Transplantation
PublisherNova Science Publishers, Inc.
Pages45-64
Number of pages20
ISBN (Print)9781624179495
StatePublished - Dec 1 2013

Keywords

  • Acute allograft rejection
  • Allograft rejection
  • Chronic allograft rejection
  • Complications
  • Microsurgery
  • Mouse kidney transplantation
  • Renal function
  • Spontaneous acceptance
  • Survival

ASJC Scopus subject areas

  • Medicine(all)

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