Kidney Vacuolar H+-ATPase: Physiology and Regulation

Patricia Valles; Michael S. Lapointe; Jan Wysocki; Daniel Batlle

doi:10.1016/j.semnephrol.2006.07.004

Kidney Vacuolar H⁺-ATPase: Physiology and Regulation

Patricia Valles, Michael S. Lapointe, Jan Wysocki, Daniel Batlle^*

^*Corresponding author for this work

Medicine, Nephrology Division

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The vacuolar H⁺-ATPase is a multisubunit protein consisting of a peripheral catalytic domain (V₁) that binds and hydrolyzes adenosine triphosphate (ATP) and provides energy to pump H⁺ through the transmembrane domain (V₀) against a large gradient. This proton-translocating vacuolar H⁺-ATPase is present in both intracellular compartments and the plasma membrane of eukaryotic cells. Mutations in genes encoding kidney intercalated cell-specific V₀ a4 and V₁ B1 subunits of the vacuolar H⁺-ATPase cause the syndrome of distal tubular renal acidosis. This review focuses on the function, regulation, and the role of vacuolar H⁺-ATPases in renal physiology. The localization of vacuolar H⁺-ATPases in the kidney, and their role in intracellular pH (pHi) regulation, transepithelial proton transport, and acid-base homeostasis are discussed.

Original language	English (US)
Pages (from-to)	361-374
Number of pages	14
Journal	Seminars in nephrology
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/j.semnephrol.2006.07.004
State	Published - Sep 1 2006

Keywords

ATP6V0A4 subunit
ATP6V1B1 subunit
distal tubular renal acidosis (dRTA)
renal vacuolar H-ATPase

ASJC Scopus subject areas

Nephrology

Access to Document

10.1016/j.semnephrol.2006.07.004

Cite this

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title = "Kidney Vacuolar H+-ATPase: Physiology and Regulation",

abstract = "The vacuolar H+-ATPase is a multisubunit protein consisting of a peripheral catalytic domain (V1) that binds and hydrolyzes adenosine triphosphate (ATP) and provides energy to pump H+ through the transmembrane domain (V0) against a large gradient. This proton-translocating vacuolar H+-ATPase is present in both intracellular compartments and the plasma membrane of eukaryotic cells. Mutations in genes encoding kidney intercalated cell-specific V0 a4 and V1 B1 subunits of the vacuolar H+-ATPase cause the syndrome of distal tubular renal acidosis. This review focuses on the function, regulation, and the role of vacuolar H+-ATPases in renal physiology. The localization of vacuolar H+-ATPases in the kidney, and their role in intracellular pH (pHi) regulation, transepithelial proton transport, and acid-base homeostasis are discussed.",

keywords = "ATP6V0A4 subunit, ATP6V1B1 subunit, distal tubular renal acidosis (dRTA), renal vacuolar H-ATPase",

author = "Patricia Valles and Lapointe, {Michael S.} and Jan Wysocki and Daniel Batlle",

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