Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone

Jessica E. Hornick, Kul Karanjeet, Elizabeth S. Collins, Edward H. Hinchcliffe*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    20 Scopus citations

    Abstract

    In mammalian cultured cells the initiation of cytokinesis is regulated - both temporally and spatially - by the overlapping, anti-parallel microtubules of the spindle midzone. This region recruits several key central spindle components: PRC-1, polo-like kinase 1 (Plk-1), the centralspindlin complex, and the chromosome passenger complex (CPC), which together serve to stabilize the microtubule overlap, and also to coordinate the assembly of the cortical actin/myosin cytoskeleton necessary to physically cleave the cell in two. The localization of these crucial elements to the spindle midzone requires members of the kinesin superfamily of microtubule-based motor proteins. Here we focus on reviewing the role played by a variety of kinesins in both building and operating the spindle midzone machinery during cytokinesis.

    Original languageEnglish (US)
    Pages (from-to)290-299
    Number of pages10
    JournalSeminars in Cell and Developmental Biology
    Volume21
    Issue number3
    DOIs
    StatePublished - May 2010

    Keywords

    • Cytokinesis
    • Kinesin
    • Microtubule
    • Mitosis
    • Motor protein

    ASJC Scopus subject areas

    • Developmental Biology
    • Cell Biology

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