It has been reported that one or both of the kinetic constants (K(m) and V(max) of monoamine oxidase (MAO) in the blood platelets of schizophrenic patients are significantly lower than those of normal controls. The authors found no significant differences in K(m) or V(max) of platelet MAO activity between schizophrenic patients, schizoaffective depressed, mainly schizophrenic patients, and normal control subjects of the same sex. There was also no relationship between paranoid symptoms, hallucinations, or a family history of schizophrenia and V(max) or K(m) of platelet MAO in the combined groups of schizophrenic and schizoaffective patients. Women had significantly higher V(max) values, but no sex difference in K(m) was noted.
ASJC Scopus subject areas
- Psychiatry and Mental health