Kinetic proofreading can explain the supression of supercoiling of circular DNA molecules by type-II topoisomerases

Jie Yan, Marcelo O. Magnasco, John F. Marko

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The mechanism of DNA topoisomerases, the enzymes that catalyze topology modification of DNA molecules in cells was modeled based on a two-step process. The model is more sensitive to the differences in collision rates between entangled and disentangled DNA molecules. It can quantitatively explained the reduction in knotting and linking complexity and can also reduced the variance of the double-helix linking number distribution.

Original languageEnglish (US)
Article number031909
Pages (from-to)319091-3190911
Number of pages2871821
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume63
Issue number3 I
DOIs
StatePublished - Mar 2001

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

Fingerprint

Dive into the research topics of 'Kinetic proofreading can explain the supression of supercoiling of circular DNA molecules by type-II topoisomerases'. Together they form a unique fingerprint.

Cite this