Kinetics of phytosterol metabolism in neonates receiving parenteral nutrition

T. Hang Nghiem-Rao*, Ilker Tunc, Alisha M. Mavis, Yumei Cao, Elizabeth M. Polzin, Mary F. Firary, Xujing Wang, Pippa M. Simpson, Shailendra B. Patel

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background:Phytosterols in soybean oil (SO) lipids likely contribute to parenteral nutrition-associated liver disease (PNALD) in infants. No characterization of phytosterol metabolism has been done in infants receiving SO lipids.Methods:In a prospective cohort study, 45 neonates (36 SO lipid vs. 9 control) underwent serial blood sample measurements of sitosterol, campesterol, and stigmasterol. Mathematical modeling was used to determine pharmacokinetic parameters of phytosterol metabolism and phytosterol exposure.Results:Compared to controls, SO lipid-exposed infants had significantly higher levels of sitosterol and campesterol (P < 0.01). During SO lipid infusion, sitosterol and campesterol reached half of steady-state plasma levels within 1.5 and 0.8 d, respectively. Steady-state level was highest for sitosterol (1.68 mg/dl), followed by campesterol (0.98 mg/dl), and lowest for stigmasterol (0.01 mg/dl). Infants born < 28 wk gestational age had higher sitosterol steady-state levels (P = 0.03) and higher area under the curve for sitosterol (P = 0.03) during the first 5 d of SO lipid (AUC 5) than infants born ≥ 28 wk gestational age.Conclusion:Phytosterols in SO lipid accumulate rapidly in neonates. Very preterm infants receiving SO lipid have higher sitosterol exposure, and may have poorly developed mechanisms of eliminating phytosterols that may contribute to their vulnerability to PNALD.

Original languageEnglish (US)
Pages (from-to)181-189
Number of pages9
JournalPediatric research
Volume78
Issue number2
DOIs
StatePublished - Aug 21 2015

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Nghiem-Rao, T. H., Tunc, I., Mavis, A. M., Cao, Y., Polzin, E. M., Firary, M. F., Wang, X., Simpson, P. M., & Patel, S. B. (2015). Kinetics of phytosterol metabolism in neonates receiving parenteral nutrition. Pediatric research, 78(2), 181-189. https://doi.org/10.1038/pr.2015.78