Kinetics of Serotonin Uptake by the Dog Lung Is pH Independent in the Physiological Range

David A. Rickaby, Christopher A. Dawson, John H. Linehan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Given the strong pH dependence of platelet serotonin uptake, the many similarities between platelet and pulmonary endothelial serotonin uptake and the potential importance of a pH dependence on the interpretation of changes in pulmonary endothelial serotonin uptake in diseased lungs, we examined the influence of pH on the kinetics of serotonin uptake in isolated dog lung lobes using a multiple indicator technique. A range of pH values from about 7.2 to 8.0 were obtained by ventilating the lobes with gas containing different concentrations of CO2. Over the pH range studied, no significant changes in serotonin uptake were observed, nor were significant changes detected in the kinetic parameters, K m and V max, for the uptake process. The lack of a significant pH effect represents a difference between platelet and lung endothelial serotonin uptake. It also indicates that correlations between P CO2 and serotonin uptake which might occur in diseased lungs do not imply causality.

Original languageEnglish (US)
Pages (from-to)361-365
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume175
Issue number3
DOIs
StatePublished - Mar 1984

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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