Kinetics of serotonin uptake in the intact lung

Christopher A. Dawson*, John H. Linehan, David A. Rickaby, Thomas A. Bronikowski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The pulmonary endothelium is capable of removing and metabolizing serotonin (5HT) carried in the venous blood. Thus the lungs can influence the arterial concentrations of 5HT. In addition, there is evidence that changes in the lung uptake of 5HT might portend more serious endothelial damage wherein the barrier function of the endothelium is compromised. This has been a stimulus for finding methods for evaluating these endothelial functions. These methods must be able to distinguish changes in whole organ function which result from changes in perfusion (e.g., cardiac output, redistribution of flow, etc.) from those resulting from changes in the function of the endothelial cells. When a bolus containing radio-labeled 5HT and an unmetabolizable indicator which is confined to the vascular space is injected into the pulmonary artery, the pulmonary venous or systemic arterial concentration curves contain information about both the convective transport and endothelial cell process involved. Some of this information can be interpreted quantitatively using a simple mathematical model.

Original languageEnglish (US)
Pages (from-to)217-227
Number of pages11
JournalAnnals of Biomedical Engineering
Volume15
Issue number2
DOIs
StatePublished - Mar 1987

Keywords

  • Carrier-mediated transport
  • Michaelis-Menten equation
  • Pulmonary endothelium

ASJC Scopus subject areas

  • Biomedical Engineering

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