KINETICS OF SEROTONIN UPTAKE IN THE INTACT LUNG.

Christopher A. Dawson*, John H. Linehan, Thomas A. Bronikowski, David A. Rickaby

*Corresponding author for this work

Research output: Contribution to journalConference article

Abstract

The uptake of serotonin by the pulmonary endothelium is a saturable process which appears to be capable of transporting the serotonin against a concentration gradient. As long as the intracellular serotonin concentration is not too large the rate of return of metabolite is slow relative to the rate of uptake and it appears that transport into the cells is normally the rate limiting step in the disappearance of serotonin from the capillary blood. For the case of the serotonin uptake we have examined the behavior of the uptake kinetic parameters of the serotonin uptake we have examined the behavior of the uptake kinetic parameters Vmax (the maximum uptake rate) and Km (the capillary concentration at Vmax/2) obtained by fitting the data to a model based on the following hypotheses: 1) Serotonin uptake is unidirectional and can be represented by the Michaelis Menten equation. 2) The transport sites are homogeneously distributed per unit capillary surface area. 3) Flow in individual capillaries is plug flow. 4) Most of the bolus dispersion occurs upstream from the capillary bed.

Original languageEnglish (US)
Pages (from-to)85-86
Number of pages2
JournalAnnals of Biomedical Engineering
Volume14
Issue number1
StatePublished - Jan 1 1986
EventBiomed Eng Soc (BES) 1986 Symp - St Louis, MO, USA
Duration: Apr 13 1986Apr 18 1986

ASJC Scopus subject areas

  • Biomedical Engineering

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