Kinetics of theophylline transfer to breast milk

G. Paul Stec; Paul Greenberger; Tsuen I. Ruo; Thomas Henthorn; Yoshio Morita; Arthur J. Atkinson; Roy Patterson

doi:10.1038/clpt.1980.180

Kinetics of theophylline transfer to breast milk

G. Paul Stec^*, Paul Greenberger, Tsuen I. Ruo, Thomas Henthorn, Yoshio Morita, Arthur J. Atkinson, Roy Patterson

^*Corresponding author for this work

Medicine, Allergy Division

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Investigation of three nursing women given theophylline intravenously defined the kinetics of theophylline transfer into breast milk. In each subject, R was constant, with no significant delay between the attainment of peak plasma and peak milk concentrations. The amount of theophylline eliminated into milk was equal to the product of R, milk volume, and the simultaneous maternal plasma concentration. The data indicate that theophylline cumulation to toxic concentrations should not occur in most breast‐fed infants of asthmatic women treated with appropriate doses of theophylline. Clinical Pharmacology and Therapeutics (1980) 28, 404–408; doi:

Original language	English (US)
Pages (from-to)	404-408
Number of pages	5
Journal	Clinical Pharmacology & Therapeutics
Volume	28
Issue number	3
DOIs	https://doi.org/10.1038/clpt.1980.180
State	Published - Sep 1980

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology

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10.1038/clpt.1980.180

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AU - Morita, Yoshio

AU - Atkinson, Arthur J.

AU - Patterson, Roy

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Kinetics of theophylline transfer to breast milk

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