Kinetics of theophylline transfer to breast milk

G. Paul Stec*, Paul Allen Greenberger, Tsuen I. Ruo, Thomas Henthorn, Yoshio Morita, Arthur J. Atkinson, Roy Patterson

*Corresponding author for this work

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Investigation of three nursing women given theophylline intravenously defined the kinetics of theophylline transfer into breast milk. In each subject, R was constant, with no significant delay between the attainment of peak plasma and peak milk concentrations. The amount of theophylline eliminated into milk was equal to the product of R, milk volume, and the simultaneous maternal plasma concentration. The data indicate that theophylline cumulation to toxic concentrations should not occur in most breast‐fed infants of asthmatic women treated with appropriate doses of theophylline. Clinical Pharmacology and Therapeutics (1980) 28, 404–408; doi:

Original languageEnglish (US)
Pages (from-to)404-408
Number of pages5
JournalClinical Pharmacology & Therapeutics
Volume28
Issue number3
DOIs
StatePublished - Jan 1 1980

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Human Milk
Theophylline
Milk
Clinical Pharmacology
Poisons
Nursing
Mothers

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Stec, G. P., Greenberger, P. A., Ruo, T. I., Henthorn, T., Morita, Y., Atkinson, A. J., & Patterson, R. (1980). Kinetics of theophylline transfer to breast milk. Clinical Pharmacology & Therapeutics, 28(3), 404-408. https://doi.org/10.1038/clpt.1980.180
Stec, G. Paul ; Greenberger, Paul Allen ; Ruo, Tsuen I. ; Henthorn, Thomas ; Morita, Yoshio ; Atkinson, Arthur J. ; Patterson, Roy. / Kinetics of theophylline transfer to breast milk. In: Clinical Pharmacology & Therapeutics. 1980 ; Vol. 28, No. 3. pp. 404-408.
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Stec, GP, Greenberger, PA, Ruo, TI, Henthorn, T, Morita, Y, Atkinson, AJ & Patterson, R 1980, 'Kinetics of theophylline transfer to breast milk', Clinical Pharmacology & Therapeutics, vol. 28, no. 3, pp. 404-408. https://doi.org/10.1038/clpt.1980.180

Kinetics of theophylline transfer to breast milk. / Stec, G. Paul; Greenberger, Paul Allen; Ruo, Tsuen I.; Henthorn, Thomas; Morita, Yoshio; Atkinson, Arthur J.; Patterson, Roy.

In: Clinical Pharmacology & Therapeutics, Vol. 28, No. 3, 01.01.1980, p. 404-408.

Research output: Contribution to journalArticle

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T1 - Kinetics of theophylline transfer to breast milk

AU - Stec, G. Paul

AU - Greenberger, Paul Allen

AU - Ruo, Tsuen I.

AU - Henthorn, Thomas

AU - Morita, Yoshio

AU - Atkinson, Arthur J.

AU - Patterson, Roy

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AB - Investigation of three nursing women given theophylline intravenously defined the kinetics of theophylline transfer into breast milk. In each subject, R was constant, with no significant delay between the attainment of peak plasma and peak milk concentrations. The amount of theophylline eliminated into milk was equal to the product of R, milk volume, and the simultaneous maternal plasma concentration. The data indicate that theophylline cumulation to toxic concentrations should not occur in most breast‐fed infants of asthmatic women treated with appropriate doses of theophylline. Clinical Pharmacology and Therapeutics (1980) 28, 404–408; doi:

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