Kinetics of theophylline transfer to breast milk

G. Paul Stec*, Paul Greenberger, Tsuen I. Ruo, Thomas Henthorn, Yoshio Morita, Arthur J. Atkinson, Roy Patterson

*Corresponding author for this work

Research output: Contribution to journalArticle

35 Scopus citations


Investigation of three nursing women given theophylline intravenously defined the kinetics of theophylline transfer into breast milk. In each subject, R was constant, with no significant delay between the attainment of peak plasma and peak milk concentrations. The amount of theophylline eliminated into milk was equal to the product of R, milk volume, and the simultaneous maternal plasma concentration. The data indicate that theophylline cumulation to toxic concentrations should not occur in most breast‐fed infants of asthmatic women treated with appropriate doses of theophylline. Clinical Pharmacology and Therapeutics (1980) 28, 404–408; doi:

Original languageEnglish (US)
Pages (from-to)404-408
Number of pages5
JournalClinical Pharmacology & Therapeutics
Issue number3
StatePublished - Sep 1980


ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Stec, G. P., Greenberger, P., Ruo, T. I., Henthorn, T., Morita, Y., Atkinson, A. J., & Patterson, R. (1980). Kinetics of theophylline transfer to breast milk. Clinical Pharmacology & Therapeutics, 28(3), 404-408.