TY - JOUR
T1 - Kleine-Levin syndrome related to pregnancy
T2 - a case report
AU - Khachatryan, Samson G.
AU - Lastra, Alejandra C.
AU - Vardanyan, Lusine V.
AU - Khachatryan, Laura G.
AU - Attarian, Hrayr P.
N1 - Publisher Copyright:
Copyright © 2022 American Academy of Sleep Medicine. All rights reserved.
PY - 2021/11
Y1 - 2021/11
N2 - Kleine-Levin syndrome (KLS) is a rare disorder of recurrent hypersomnolence. The pathophysiology continues to be poorly understood. Autoimmunity, genetic polymorphisms, dysfunction of the hypothalamic axis, and abnormalities in functional imaging have been proposed. Several triggers have been described, including infection, toxins, head trauma, sleep deprivation, lactation, and menses. We present the first case report in the medical literature of KLS triggered by pregnancy and the first case of KLS from Armenia. Our patient has a pattern of mostly pregnancy-related episodes of several day sleepiness occurring monthly. This case adds to the published literature as we present a new association and explore the pathophysiology of KLS.
AB - Kleine-Levin syndrome (KLS) is a rare disorder of recurrent hypersomnolence. The pathophysiology continues to be poorly understood. Autoimmunity, genetic polymorphisms, dysfunction of the hypothalamic axis, and abnormalities in functional imaging have been proposed. Several triggers have been described, including infection, toxins, head trauma, sleep deprivation, lactation, and menses. We present the first case report in the medical literature of KLS triggered by pregnancy and the first case of KLS from Armenia. Our patient has a pattern of mostly pregnancy-related episodes of several day sleepiness occurring monthly. This case adds to the published literature as we present a new association and explore the pathophysiology of KLS.
KW - KLS
KW - Kleine-Levin syndrome
KW - lactation
KW - menstrual-related hypersomnia
KW - pregnancy
KW - recurrent hypersomnia
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U2 - 10.5664/jcsm.9482
DO - 10.5664/jcsm.9482
M3 - Article
C2 - 34170245
AN - SCOPUS:85119829822
SN - 1550-9389
VL - 17
SP - 2325
EP - 2327
JO - Journal of Clinical Sleep Medicine
JF - Journal of Clinical Sleep Medicine
IS - 11
ER -