Kleine-Levin syndrome related to pregnancy: a case report

Samson G. Khachatryan, Alejandra C. Lastra, Lusine V. Vardanyan, Laura G. Khachatryan, Hrayr P. Attarian

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Kleine-Levin syndrome (KLS) is a rare disorder of recurrent hypersomnolence. The pathophysiology continues to be poorly understood. Autoimmunity, genetic polymorphisms, dysfunction of the hypothalamic axis, and abnormalities in functional imaging have been proposed. Several triggers have been described, including infection, toxins, head trauma, sleep deprivation, lactation, and menses. We present the first case report in the medical literature of KLS triggered by pregnancy and the first case of KLS from Armenia. Our patient has a pattern of mostly pregnancy-related episodes of several day sleepiness occurring monthly. This case adds to the published literature as we present a new association and explore the pathophysiology of KLS.

Original languageEnglish (US)
Pages (from-to)2325-2327
Number of pages3
JournalJournal of Clinical Sleep Medicine
Issue number11
StatePublished - Nov 2021


  • KLS
  • Kleine-Levin syndrome
  • lactation
  • menstrual-related hypersomnia
  • pregnancy
  • recurrent hypersomnia

ASJC Scopus subject areas

  • Medicine(all)


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