Knowledge, attitudes, and self-efficacy as predictors of preparedness for oncology clinical trials: A mediational model

Sharon Manne*, Deborah Kashy, Terrance Albrecht, Yu Ning Wong, Anne Lederman Flamm, Al B. Benson, Suzanne M. Miller, Linda Fleisher, Joanne Buzaglo, Nancy Roach, Michael Katz, Eric Ross, Michael Collins, David Poole, Stephanie Raivitch, Dawn M. Miller, Tyler G. Kinzy, Tasnuva Liu, Neal J. Meropol

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Objective. This study used the Ottawa Decision Support Framework to evaluate a model examining associations between clinical trial knowledge, attitudinal barriers to participating in clinical trials, clinical trial self-efficacy, and clinical trial preparedness among 1256 cancer patients seen for their first outpatient consultation at a cancer center. As an exploratory aim, moderator effects for gender, race/ethnicity, education, and metastatic status on associations in the model were evaluated. Methods. Patients completed measures of cancer clinical trial knowledge, attitudinal barriers, self-efficacy, and preparedness. Structural equation modeling (SEM) was conducted to evaluate whether self-efficacy mediated the association between knowledge and barriers with preparedness. Results. The SEM explained 26% of the variance in cancer clinical trial preparedness. Self-efficacy mediated the associations between attitudinal barriers and preparedness, but self-efficacy did not mediate the knowledge-preparedness relationship. Conclusions. Findings partially support the Ottawa Decision Support Framework and suggest that assessing patients' level of self-efficacy may be just as important as evaluating their knowledge and attitudes about cancer clinical trials.

Original languageEnglish (US)
Pages (from-to)454-463
Number of pages10
JournalMedical Decision Making
Volume34
Issue number4
DOIs
StatePublished - May 2014

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Keywords

  • Ottawa Decision Support Framework
  • cancer clinical trials
  • cancer patients

ASJC Scopus subject areas

  • Health Policy

Cite this

Manne, S., Kashy, D., Albrecht, T., Wong, Y. N., Flamm, A. L., Benson, A. B., Miller, S. M., Fleisher, L., Buzaglo, J., Roach, N., Katz, M., Ross, E., Collins, M., Poole, D., Raivitch, S., Miller, D. M., Kinzy, T. G., Liu, T., & Meropol, N. J. (2014). Knowledge, attitudes, and self-efficacy as predictors of preparedness for oncology clinical trials: A mediational model. Medical Decision Making, 34(4), 454-463. https://doi.org/10.1177/0272989X13511704