Krüppel-like factors in cancer

Marie Pier Tetreault; Yizeng Yang; Jonathan P. Katz

doi:10.1038/nrc3582

Krüppel-like factors in cancer

Marie Pier Tetreault, Yizeng Yang, Jonathan P. Katz^*

^*Corresponding author for this work

Medicine, Gastroenterology Division

Research output: Contribution to journal › Review article › peer-review

305 Scopus citations

Abstract

Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.

Original language	English (US)
Pages (from-to)	701-713
Number of pages	13
Journal	Nature Reviews Cancer
Volume	13
Issue number	10
DOIs	https://doi.org/10.1038/nrc3582
State	Published - Oct 2013

Funding

The authors acknowledge support from US National Institutes of Health (NIH) NIDDK R01 DK069984 (to J.P.K.), by NIH NIDDK K99 DK094977 (to M.P.T.) and from the University of Pennsylvania Center for Molecular Studies in Digestive and Liver Diseases (NIH NIDDK P30 DK050306) and NIH NCI P01 CA098101.

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrc3582

Cite this

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title = "Kr{\"u}ppel-like factors in cancer",

abstract = "Kr{\"u}ppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.",

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note = "Funding Information: The authors acknowledge support from US National Institutes of Health (NIH) NIDDK R01 DK069984 (to J.P.K.), by NIH NIDDK K99 DK094977 (to M.P.T.) and from the University of Pennsylvania Center for Molecular Studies in Digestive and Liver Diseases (NIH NIDDK P30 DK050306) and NIH NCI P01 CA098101.",

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AB - Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.

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Krüppel-like factors in cancer

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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