Abstract
Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.
Original language | English (US) |
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Pages (from-to) | 701-713 |
Number of pages | 13 |
Journal | Nature Reviews Cancer |
Volume | 13 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2013 |
Funding
The authors acknowledge support from US National Institutes of Health (NIH) NIDDK R01 DK069984 (to J.P.K.), by NIH NIDDK K99 DK094977 (to M.P.T.) and from the University of Pennsylvania Center for Molecular Studies in Digestive and Liver Diseases (NIH NIDDK P30 DK050306) and NIH NCI P01 CA098101.
ASJC Scopus subject areas
- Oncology
- Cancer Research