Krüppel-like factors in cancer

Marie Pier Tetreault, Yizeng Yang, Jonathan P. Katz*

*Corresponding author for this work

Research output: Contribution to journalReview article

174 Scopus citations

Abstract

Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.

Original languageEnglish (US)
Pages (from-to)701-713
Number of pages13
JournalNature Reviews Cancer
Volume13
Issue number10
DOIs
StatePublished - Oct 1 2013

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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