TY - JOUR
T1 - Krüppel-like factors in cancer
AU - Tetreault, Marie Pier
AU - Yang, Yizeng
AU - Katz, Jonathan P.
N1 - Funding Information:
The authors acknowledge support from US National Institutes of Health (NIH) NIDDK R01 DK069984 (to J.P.K.), by NIH NIDDK K99 DK094977 (to M.P.T.) and from the University of Pennsylvania Center for Molecular Studies in Digestive and Liver Diseases (NIH NIDDK P30 DK050306) and NIH NCI P01 CA098101.
PY - 2013/10
Y1 - 2013/10
N2 - Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.
AB - Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.
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U2 - 10.1038/nrc3582
DO - 10.1038/nrc3582
M3 - Review article
C2 - 24060862
AN - SCOPUS:84884567199
SN - 1474-175X
VL - 13
SP - 701
EP - 713
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 10
ER -
