L-carnitine treatment of anemia

Thomas A. Golper*, Simin Goral, Bryan N. Becker, Craig B. Langman

*Corresponding author for this work

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Recombinant human erythropoietin (rHuEPO) and iron supplementation have had a profoundly positive impact on the anemia of patients with chronic kidney disease. However, a significant number of patients remain hyporesponsive to rHuEPO, with hemoglobin values less than target levels. A suboptimal response to rHuEPO is associated with complications that can reduce quality of life and increase morbidity, mortality, and costs. There are a number of other metabolic derangements associated with uremia that can impact on the production and survival of red blood cells. Dialysis-related carnitine disorder is a functional metabolic deficiency, common in chronic dialysis patients, that can have a negative impact on erythrocyte production and survival. This article reviews the role of L-carnitine in the pathogenesis and adjunctive treatment of anemia associated with kidney failure. After a comprehensive database search, primary and secondary reports were analyzed. Laboratory studies examining the influence of carnitine on red blood cell function and clinical trials of L-carnitine in dialysis patients support the use of L-carnitine in the setting of rHuEPO hyporesponsiveness. Consensus groups, including the National Kidney Foundation-Kidney Disease Outcome Quality Initiative (K/DOQI), consider the use of L-carnitine for hyporesponsive rHuEPO-dependent anemia a promising application of this therapy, recommending an empiric trial of L-carnitine in these patients.

Original languageEnglish (US)
Pages (from-to)S27-S34
JournalAmerican Journal of Kidney Diseases
Volume41
Issue number4 SUPPL. 4
DOIs
StatePublished - Apr 1 2003

Keywords

  • Anemia
  • Carnitine
  • Chronic renal failure (CRF)
  • Dialysis
  • End-stage renal disease (ESRD)
  • Epoetin
  • Epoetin resistance
  • Kidney failure
  • L-carnitine
  • Levocarnitine
  • Uremia

ASJC Scopus subject areas

  • Nephrology

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