Abstract
To the Editor: I read with interest the letter of Drs. Mars and Krall in the December 16, 1971, issue of the Journal (285:1437, 1971) and should like to call attention to some recent work in our laboratory.1,2 which may be pertinent to their findings and which may explain the arrhythmogenic potential of L-dopa. In experiments using 3H-norepinephrine as a tracer, L-dopa administered to Sprague-Dawley rats resulted in a significant dose-related release of norepinephrine (NE) from the sympathetic nerve endings of the heart. Ganglionic blockade did not prevent the release of cardiac NE, thus indicating a direct effect of L-dopa. No extract is available for articles shorter than 400 words.
| Original language | English (US) |
|---|---|
| Number of pages | 1 |
| Journal | New England Journal of Medicine |
| Volume | 286 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 27 1972 |
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- Medicine(all)
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L-Dopa and Cardiac Arrhythmia (Cont.). / Landsberg, L.
In: New England Journal of Medicine, Vol. 286, No. 4, 27.01.1972.Research output: Contribution to journal › Letter
TY - JOUR
T1 - L-Dopa and Cardiac Arrhythmia (Cont.)
AU - Landsberg, L.
PY - 1972/1/27
Y1 - 1972/1/27
N2 - To the Editor: I read with interest the letter of Drs. Mars and Krall in the December 16, 1971, issue of the Journal (285:1437, 1971) and should like to call attention to some recent work in our laboratory.1,2 which may be pertinent to their findings and which may explain the arrhythmogenic potential of L-dopa. In experiments using 3H-norepinephrine as a tracer, L-dopa administered to Sprague-Dawley rats resulted in a significant dose-related release of norepinephrine (NE) from the sympathetic nerve endings of the heart. Ganglionic blockade did not prevent the release of cardiac NE, thus indicating a direct effect of L-dopa. No extract is available for articles shorter than 400 words.
AB - To the Editor: I read with interest the letter of Drs. Mars and Krall in the December 16, 1971, issue of the Journal (285:1437, 1971) and should like to call attention to some recent work in our laboratory.1,2 which may be pertinent to their findings and which may explain the arrhythmogenic potential of L-dopa. In experiments using 3H-norepinephrine as a tracer, L-dopa administered to Sprague-Dawley rats resulted in a significant dose-related release of norepinephrine (NE) from the sympathetic nerve endings of the heart. Ganglionic blockade did not prevent the release of cardiac NE, thus indicating a direct effect of L-dopa. No extract is available for articles shorter than 400 words.
UR - http://www.scopus.com/inward/record.url?scp=0015525535&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015525535&partnerID=8YFLogxK
U2 - 10.1056/NEJM197201272860416
DO - 10.1056/NEJM197201272860416
M3 - Letter
C2 - 5007131
AN - SCOPUS:0015525535
VL - 286
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 4
ER -