L-Dopa and Cardiac Arrhythmia (Cont.)

L. Landsberg*

*Corresponding author for this work

Research output: Contribution to journalLetter

1 Citation (Scopus)

Abstract

To the Editor: I read with interest the letter of Drs. Mars and Krall in the December 16, 1971, issue of the Journal (285:1437, 1971) and should like to call attention to some recent work in our laboratory.1,2 which may be pertinent to their findings and which may explain the arrhythmogenic potential of L-dopa. In experiments using 3H-norepinephrine as a tracer, L-dopa administered to Sprague-Dawley rats resulted in a significant dose-related release of norepinephrine (NE) from the sympathetic nerve endings of the heart. Ganglionic blockade did not prevent the release of cardiac NE, thus indicating a direct effect of L-dopa. No extract is available for articles shorter than 400 words.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume286
Issue number4
DOIs
StatePublished - Jan 27 1972

Fingerprint

Levodopa
Cardiac Arrhythmias
Norepinephrine
Mars
Nerve Endings
Sprague Dawley Rats

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "L-Dopa and Cardiac Arrhythmia (Cont.)",
abstract = "To the Editor: I read with interest the letter of Drs. Mars and Krall in the December 16, 1971, issue of the Journal (285:1437, 1971) and should like to call attention to some recent work in our laboratory.1,2 which may be pertinent to their findings and which may explain the arrhythmogenic potential of L-dopa. In experiments using 3H-norepinephrine as a tracer, L-dopa administered to Sprague-Dawley rats resulted in a significant dose-related release of norepinephrine (NE) from the sympathetic nerve endings of the heart. Ganglionic blockade did not prevent the release of cardiac NE, thus indicating a direct effect of L-dopa. No extract is available for articles shorter than 400 words.",
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L-Dopa and Cardiac Arrhythmia (Cont.). / Landsberg, L.

In: New England Journal of Medicine, Vol. 286, No. 4, 27.01.1972.

Research output: Contribution to journalLetter

TY - JOUR

T1 - L-Dopa and Cardiac Arrhythmia (Cont.)

AU - Landsberg, L.

PY - 1972/1/27

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AB - To the Editor: I read with interest the letter of Drs. Mars and Krall in the December 16, 1971, issue of the Journal (285:1437, 1971) and should like to call attention to some recent work in our laboratory.1,2 which may be pertinent to their findings and which may explain the arrhythmogenic potential of L-dopa. In experiments using 3H-norepinephrine as a tracer, L-dopa administered to Sprague-Dawley rats resulted in a significant dose-related release of norepinephrine (NE) from the sympathetic nerve endings of the heart. Ganglionic blockade did not prevent the release of cardiac NE, thus indicating a direct effect of L-dopa. No extract is available for articles shorter than 400 words.

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