Abstract
(Figure Presented) Eliminating the middle-man: The combination of MALDI-TOF mass spectrometry and self-assembled monolayers on gold (SAMDI) offers a new detection method for protein-ligand (shown) and protein-protein interactions. Proteins and protein complexes are selectively bound to biochips and then directly analyzed by MALDI-TOF MS without the need for labels.
Original language | English (US) |
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Pages (from-to) | 5480-5483 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 44 |
Issue number | 34 |
DOIs | |
State | Published - Sep 2 2005 |
Keywords
- Bioinformatics
- Immobilization
- Mass spectrometry
- Monolayers
- Proteins
ASJC Scopus subject areas
- General Chemistry
- Catalysis