Label-free detection of protein-protein interactions on biochips

Woon Seok Yeo*, Dal Hee Min, Robert W. Hsieh, Geoffrey L. Greene, Milan Mrksich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


(Figure Presented) Eliminating the middle-man: The combination of MALDI-TOF mass spectrometry and self-assembled monolayers on gold (SAMDI) offers a new detection method for protein-ligand (shown) and protein-protein interactions. Proteins and protein complexes are selectively bound to biochips and then directly analyzed by MALDI-TOF MS without the need for labels.

Original languageEnglish (US)
Pages (from-to)5480-5483
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number34
StatePublished - Sep 2 2005


  • Bioinformatics
  • Immobilization
  • Mass spectrometry
  • Monolayers
  • Proteins

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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