Label-free optical biosensors for virus detection and characterization

George G. Daaboul*, Carlos A. Lopez, Abdulkadir Yurt, Bennett B. Goldberg, John H. Connor, M. Selim Ünlü

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Label-free optical biosensors have shown promise in rapid and sensitive detection of viruses. Recently, we have demonstrated a technique termed interferometric reflectance imaging sensor (IRIS) capable of detecting viral antigens and single viruses in a high-throughput, quantitative, and label-free fashion. In this paper, we briefly review the current label-free optical methods that have demonstrated virus detection through ensemble measurements of viral antigen and emerging techniques that are capable of detecting individual viruses captured by the sensor. We then present the principle of single nanoparticle detection using IRIS and show proof-of-principle results on specific detection and shape analysis of individual viruses captured on the IRIS platform.

Original languageEnglish (US)
Article number6109303
Pages (from-to)1422-1433
Number of pages12
JournalIEEE Journal on Selected Topics in Quantum Electronics
Issue number4
StatePublished - 2012


  • Biosensing
  • high throughput
  • interferometry
  • label free
  • nanoparticle
  • single virus

ASJC Scopus subject areas

  • Ceramics and Composites
  • Atomic and Molecular Physics, and Optics
  • Materials Chemistry
  • Electrical and Electronic Engineering


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