TY - JOUR
T1 - Labelling polymers and micellar nanoparticles via initiation, propagation and termination with ROMP
AU - Thompson, Matthew P.
AU - Randolph, Lyndsay M.
AU - James, Carrie R.
AU - Davalos, Ashley N.
AU - Hahn, Michael E.
AU - Gianneschi, Nathan C.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2014/3/21
Y1 - 2014/3/21
N2 - In this paper we compare and contrast three approaches for labelling polymers with functional groups via ring-opening metathesis polymerization (ROMP). We explored the incorporation of functionality via initiation, termination and propagation employing an array of novel initiators, termination agents and monomers. The goal was to allow the generation of selectively labelled and well-defined polymers that would in turn lead to the formation of labelled nanomaterials. Norbornene analogues, prepared as functionalized monomers for ROMP, included fluorescent dyes (rhodamine, fluorescein, EDANS, and coumarin), quenchers (DABCYL), conjugatable moieties (NHS esters, pentafluorophenyl esters), and protected amines. In addition, a set of symmetrical olefins for terminally labelling polymers, and for the generation of initiators in situ is described.
AB - In this paper we compare and contrast three approaches for labelling polymers with functional groups via ring-opening metathesis polymerization (ROMP). We explored the incorporation of functionality via initiation, termination and propagation employing an array of novel initiators, termination agents and monomers. The goal was to allow the generation of selectively labelled and well-defined polymers that would in turn lead to the formation of labelled nanomaterials. Norbornene analogues, prepared as functionalized monomers for ROMP, included fluorescent dyes (rhodamine, fluorescein, EDANS, and coumarin), quenchers (DABCYL), conjugatable moieties (NHS esters, pentafluorophenyl esters), and protected amines. In addition, a set of symmetrical olefins for terminally labelling polymers, and for the generation of initiators in situ is described.
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U2 - 10.1039/c3py01338c
DO - 10.1039/c3py01338c
M3 - Article
AN - SCOPUS:84894417090
VL - 5
SP - 1954
EP - 1964
JO - Polymer Chemistry
JF - Polymer Chemistry
SN - 1759-9954
IS - 6
ER -