Labor patterns in women attempting vaginal birth after cesarean with normal neonatal outcomes

Katherine L. Grantz*, Victor Gonzalez-Quintero, James Troendle, Uma M. Reddy, Stefanie N. Hinkle, Michelle A. Kominiarek, Zhaohui Lu, Jun Zhang

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective We sought to describe labor patterns in women with a trial of labor after cesarean (TOLAC) with normal neonatal outcomes. Study Design In a retrospective observational study at 12 US centers (2002 through 2008), we examined time interval for each centimeter of cervical dilation and compared labor progression stratified by spontaneous or induced labor in 2892 multiparous women with TOLAC (second delivery) and 56,301 nulliparous women at 37 0/7 to 41 6/7 weeks of gestation. Analyses were performed including women with intrapartum cesarean delivery, and also limiting only to women who delivered vaginally. Results Labor was induced in 23.4% of TOLAC and 44.1% of nulliparous women (P <.001). Cesarean delivery rates were 57.7% in TOLAC vs 19.0% in nulliparous women (P <.001). Oxytocin was used in 52.4% of TOLAC vs 64.3% of nulliparous women with spontaneous labor (P <.001) and 89.8% of TOLAC vs 91.6% of nulliparous women with induced labor (P =.099); however, TOLAC had lower maximum doses of oxytocin compared to nulliparous women: median (90th percentile): 6 (18) mU/min vs 12 (28) mU/min, respectively (P <.001). Median (95th percentile) labor duration for TOLAC vs nulliparous women with spontaneous labor from 4-10 cm was 0.9 (2.2) hours longer (P =.007). For women who entered labor spontaneously and achieved vaginal delivery, labor patterns for TOLAC were similar to nulliparous women. For induced labor, labor duration for TOLAC vs nulliparous women from 4-10 cm was 1.5 (4.6) hours longer (P <.001). For women who achieved vaginal delivery, labor patterns were slower for induced TOLAC compared to nulliparous women. Conclusion Labor duration for TOLAC was slower compared to nulliparous labor, particularly for induced labor. By improved understanding of the rates of progress at different points in labor, this new information on labor curves in women undergoing TOLAC, particularly for induction, should help physicians when managing labor.

Original languageEnglish (US)
Pages (from-to)226.e1-226.e6
JournalAmerican journal of obstetrics and gynecology
Volume213
Issue number2
DOIs
StatePublished - Aug 1 2015

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Vaginal Birth after Cesarean
Trial of Labor
Induced Labor
Oxytocin

Keywords

  • first stage of labor
  • trial of labor after cesarean
  • vaginal birth after cesarean

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Grantz, Katherine L. ; Gonzalez-Quintero, Victor ; Troendle, James ; Reddy, Uma M. ; Hinkle, Stefanie N. ; Kominiarek, Michelle A. ; Lu, Zhaohui ; Zhang, Jun. / Labor patterns in women attempting vaginal birth after cesarean with normal neonatal outcomes. In: American journal of obstetrics and gynecology. 2015 ; Vol. 213, No. 2. pp. 226.e1-226.e6.
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title = "Labor patterns in women attempting vaginal birth after cesarean with normal neonatal outcomes",
abstract = "Objective We sought to describe labor patterns in women with a trial of labor after cesarean (TOLAC) with normal neonatal outcomes. Study Design In a retrospective observational study at 12 US centers (2002 through 2008), we examined time interval for each centimeter of cervical dilation and compared labor progression stratified by spontaneous or induced labor in 2892 multiparous women with TOLAC (second delivery) and 56,301 nulliparous women at 37 0/7 to 41 6/7 weeks of gestation. Analyses were performed including women with intrapartum cesarean delivery, and also limiting only to women who delivered vaginally. Results Labor was induced in 23.4{\%} of TOLAC and 44.1{\%} of nulliparous women (P <.001). Cesarean delivery rates were 57.7{\%} in TOLAC vs 19.0{\%} in nulliparous women (P <.001). Oxytocin was used in 52.4{\%} of TOLAC vs 64.3{\%} of nulliparous women with spontaneous labor (P <.001) and 89.8{\%} of TOLAC vs 91.6{\%} of nulliparous women with induced labor (P =.099); however, TOLAC had lower maximum doses of oxytocin compared to nulliparous women: median (90th percentile): 6 (18) mU/min vs 12 (28) mU/min, respectively (P <.001). Median (95th percentile) labor duration for TOLAC vs nulliparous women with spontaneous labor from 4-10 cm was 0.9 (2.2) hours longer (P =.007). For women who entered labor spontaneously and achieved vaginal delivery, labor patterns for TOLAC were similar to nulliparous women. For induced labor, labor duration for TOLAC vs nulliparous women from 4-10 cm was 1.5 (4.6) hours longer (P <.001). For women who achieved vaginal delivery, labor patterns were slower for induced TOLAC compared to nulliparous women. Conclusion Labor duration for TOLAC was slower compared to nulliparous labor, particularly for induced labor. By improved understanding of the rates of progress at different points in labor, this new information on labor curves in women undergoing TOLAC, particularly for induction, should help physicians when managing labor.",
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Grantz, KL, Gonzalez-Quintero, V, Troendle, J, Reddy, UM, Hinkle, SN, Kominiarek, MA, Lu, Z & Zhang, J 2015, 'Labor patterns in women attempting vaginal birth after cesarean with normal neonatal outcomes', American journal of obstetrics and gynecology, vol. 213, no. 2, pp. 226.e1-226.e6. https://doi.org/10.1016/j.ajog.2015.04.033

Labor patterns in women attempting vaginal birth after cesarean with normal neonatal outcomes. / Grantz, Katherine L.; Gonzalez-Quintero, Victor; Troendle, James; Reddy, Uma M.; Hinkle, Stefanie N.; Kominiarek, Michelle A.; Lu, Zhaohui; Zhang, Jun.

In: American journal of obstetrics and gynecology, Vol. 213, No. 2, 01.08.2015, p. 226.e1-226.e6.

Research output: Contribution to journalArticle

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T1 - Labor patterns in women attempting vaginal birth after cesarean with normal neonatal outcomes

AU - Grantz, Katherine L.

AU - Gonzalez-Quintero, Victor

AU - Troendle, James

AU - Reddy, Uma M.

AU - Hinkle, Stefanie N.

AU - Kominiarek, Michelle A.

AU - Lu, Zhaohui

AU - Zhang, Jun

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Objective We sought to describe labor patterns in women with a trial of labor after cesarean (TOLAC) with normal neonatal outcomes. Study Design In a retrospective observational study at 12 US centers (2002 through 2008), we examined time interval for each centimeter of cervical dilation and compared labor progression stratified by spontaneous or induced labor in 2892 multiparous women with TOLAC (second delivery) and 56,301 nulliparous women at 37 0/7 to 41 6/7 weeks of gestation. Analyses were performed including women with intrapartum cesarean delivery, and also limiting only to women who delivered vaginally. Results Labor was induced in 23.4% of TOLAC and 44.1% of nulliparous women (P <.001). Cesarean delivery rates were 57.7% in TOLAC vs 19.0% in nulliparous women (P <.001). Oxytocin was used in 52.4% of TOLAC vs 64.3% of nulliparous women with spontaneous labor (P <.001) and 89.8% of TOLAC vs 91.6% of nulliparous women with induced labor (P =.099); however, TOLAC had lower maximum doses of oxytocin compared to nulliparous women: median (90th percentile): 6 (18) mU/min vs 12 (28) mU/min, respectively (P <.001). Median (95th percentile) labor duration for TOLAC vs nulliparous women with spontaneous labor from 4-10 cm was 0.9 (2.2) hours longer (P =.007). For women who entered labor spontaneously and achieved vaginal delivery, labor patterns for TOLAC were similar to nulliparous women. For induced labor, labor duration for TOLAC vs nulliparous women from 4-10 cm was 1.5 (4.6) hours longer (P <.001). For women who achieved vaginal delivery, labor patterns were slower for induced TOLAC compared to nulliparous women. Conclusion Labor duration for TOLAC was slower compared to nulliparous labor, particularly for induced labor. By improved understanding of the rates of progress at different points in labor, this new information on labor curves in women undergoing TOLAC, particularly for induction, should help physicians when managing labor.

AB - Objective We sought to describe labor patterns in women with a trial of labor after cesarean (TOLAC) with normal neonatal outcomes. Study Design In a retrospective observational study at 12 US centers (2002 through 2008), we examined time interval for each centimeter of cervical dilation and compared labor progression stratified by spontaneous or induced labor in 2892 multiparous women with TOLAC (second delivery) and 56,301 nulliparous women at 37 0/7 to 41 6/7 weeks of gestation. Analyses were performed including women with intrapartum cesarean delivery, and also limiting only to women who delivered vaginally. Results Labor was induced in 23.4% of TOLAC and 44.1% of nulliparous women (P <.001). Cesarean delivery rates were 57.7% in TOLAC vs 19.0% in nulliparous women (P <.001). Oxytocin was used in 52.4% of TOLAC vs 64.3% of nulliparous women with spontaneous labor (P <.001) and 89.8% of TOLAC vs 91.6% of nulliparous women with induced labor (P =.099); however, TOLAC had lower maximum doses of oxytocin compared to nulliparous women: median (90th percentile): 6 (18) mU/min vs 12 (28) mU/min, respectively (P <.001). Median (95th percentile) labor duration for TOLAC vs nulliparous women with spontaneous labor from 4-10 cm was 0.9 (2.2) hours longer (P =.007). For women who entered labor spontaneously and achieved vaginal delivery, labor patterns for TOLAC were similar to nulliparous women. For induced labor, labor duration for TOLAC vs nulliparous women from 4-10 cm was 1.5 (4.6) hours longer (P <.001). For women who achieved vaginal delivery, labor patterns were slower for induced TOLAC compared to nulliparous women. Conclusion Labor duration for TOLAC was slower compared to nulliparous labor, particularly for induced labor. By improved understanding of the rates of progress at different points in labor, this new information on labor curves in women undergoing TOLAC, particularly for induction, should help physicians when managing labor.

KW - first stage of labor

KW - trial of labor after cesarean

KW - vaginal birth after cesarean

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