Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples

Yuko Hirata, Renan P. Souza, Jeffrey A. Lieberman, Herbert Y. Meltzer, James L. Kennedy*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Previous studies have found haplotypic association of HTR4 variants and schizophrenia. Examining case-control pairs, G-G of rs7713886 was associated with schizophrenia risk. The A-A-G-G-G-A-A rs9325104-rs1422636-rs7715569-rs6873382-rs7711800-rs10078551-rs2068190 haplotype was overrepresented in the schizophrenia cases. The associations were no longer significant after corrections for multiple comparisons. No association was found in the family sample.

Original languageEnglish (US)
Pages (from-to)176-178
Number of pages3
JournalPsychiatry Research
Volume175
Issue number1-2
DOIs
StatePublished - Jan 30 2010

Keywords

  • 5-HT4
  • Schizophrenia
  • Serotonin receptor 4

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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