Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples

Yuko Hirata; Renan P. Souza; Jeffrey A. Lieberman; Herbert Y. Meltzer; James L. Kennedy

doi:10.1016/j.psychres.2009.08.005

Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples

Yuko Hirata, Renan P. Souza, Jeffrey A. Lieberman, Herbert Y. Meltzer, James L. Kennedy^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Previous studies have found haplotypic association of HTR4 variants and schizophrenia. Examining case-control pairs, G-G of rs7713886 was associated with schizophrenia risk. The A-A-G-G-G-A-A rs9325104-rs1422636-rs7715569-rs6873382-rs7711800-rs10078551-rs2068190 haplotype was overrepresented in the schizophrenia cases. The associations were no longer significant after corrections for multiple comparisons. No association was found in the family sample.

Original language	English (US)
Pages (from-to)	176-178
Number of pages	3
Journal	Psychiatry Research
Volume	175
Issue number	1-2
DOIs	https://doi.org/10.1016/j.psychres.2009.08.005
State	Published - Jan 30 2010

Keywords

5-HT4
Schizophrenia
Serotonin receptor 4

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2009.08.005

Cite this

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title = "Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples",

abstract = "Previous studies have found haplotypic association of HTR4 variants and schizophrenia. Examining case-control pairs, G-G of rs7713886 was associated with schizophrenia risk. The A-A-G-G-G-A-A rs9325104-rs1422636-rs7715569-rs6873382-rs7711800-rs10078551-rs2068190 haplotype was overrepresented in the schizophrenia cases. The associations were no longer significant after corrections for multiple comparisons. No association was found in the family sample.",

keywords = "5-HT4, Schizophrenia, Serotonin receptor 4",

author = "Yuko Hirata and Souza, {Renan P.} and Lieberman, {Jeffrey A.} and Meltzer, {Herbert Y.} and Kennedy, {James L.}",

note = "Funding Information: Funding: Canadian Institutes of Health Research (CIHR # MOP-49525 ; PI to JLK; CIHR # 200508GMH ; PI to J. Culotti). Dr. Hirata is supported by a CAMH postdoctoral fellowship award. The authors thank Mary Smirniw and Nicole King for their help and support throughout the manuscript preparation. ",

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doi = "10.1016/j.psychres.2009.08.005",

language = "English (US)",

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AU - Hirata, Yuko

AU - Souza, Renan P.

AU - Lieberman, Jeffrey A.

AU - Meltzer, Herbert Y.

AU - Kennedy, James L.

N1 - Funding Information: Funding: Canadian Institutes of Health Research (CIHR # MOP-49525 ; PI to JLK; CIHR # 200508GMH ; PI to J. Culotti). Dr. Hirata is supported by a CAMH postdoctoral fellowship award. The authors thank Mary Smirniw and Nicole King for their help and support throughout the manuscript preparation.

PY - 2010/1/30

Y1 - 2010/1/30

N2 - Previous studies have found haplotypic association of HTR4 variants and schizophrenia. Examining case-control pairs, G-G of rs7713886 was associated with schizophrenia risk. The A-A-G-G-G-A-A rs9325104-rs1422636-rs7715569-rs6873382-rs7711800-rs10078551-rs2068190 haplotype was overrepresented in the schizophrenia cases. The associations were no longer significant after corrections for multiple comparisons. No association was found in the family sample.

AB - Previous studies have found haplotypic association of HTR4 variants and schizophrenia. Examining case-control pairs, G-G of rs7713886 was associated with schizophrenia risk. The A-A-G-G-G-A-A rs9325104-rs1422636-rs7715569-rs6873382-rs7711800-rs10078551-rs2068190 haplotype was overrepresented in the schizophrenia cases. The associations were no longer significant after corrections for multiple comparisons. No association was found in the family sample.

KW - 5-HT4

KW - Schizophrenia

KW - Serotonin receptor 4

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Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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