Lack of association of NALCN genetic variants with schizophrenia

Renan P. Souza; Daniela V F Rosa; Marco A. Romano-Silva; Mei Zhen; Herbert Y. Meltzer; Jeffrey A. Lieberman; Gary Remington; James L. Kennedy; Albert H C Wong

doi:10.1016/j.psychres.2010.07.009

Lack of association of NALCN genetic variants with schizophrenia

Renan P. Souza^*, Daniela V F Rosa, Marco A. Romano-Silva, Mei Zhen, Herbert Y. Meltzer, Jeffrey A. Lieberman, Gary Remington, James L. Kennedy, Albert H C Wong

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

NALCN (sodium leak channel, non-selective) is located on chromosome 13q (suggested linkage region for schizophrenia). We analyzed 21 polymorphisms in 464 schizophrenia subjects, 220 controls subjects and 119 small nuclear families. We observed nominal association with rs9518320 and rs9518331, suggesting that NALCN is not related to schizophrenia risk.

Original language	English (US)
Pages (from-to)	450-452
Number of pages	3
Journal	Psychiatry Research
Volume	185
Issue number	3
DOIs	https://doi.org/10.1016/j.psychres.2010.07.009
State	Published - Feb 28 2011

Keywords

Genetic association
NALCN
Schizophrenia
VGCNL

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2010.07.009

Cite this

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title = "Lack of association of NALCN genetic variants with schizophrenia",

abstract = "NALCN (sodium leak channel, non-selective) is located on chromosome 13q (suggested linkage region for schizophrenia). We analyzed 21 polymorphisms in 464 schizophrenia subjects, 220 controls subjects and 119 small nuclear families. We observed nominal association with rs9518320 and rs9518331, suggesting that NALCN is not related to schizophrenia risk.",

keywords = "Genetic association, NALCN, Schizophrenia, VGCNL",

author = "Souza, {Renan P.} and Rosa, {Daniela V F} and Romano-Silva, {Marco A.} and Mei Zhen and Meltzer, {Herbert Y.} and Lieberman, {Jeffrey A.} and Gary Remington and Kennedy, {James L.} and Wong, {Albert H C}",

note = "Funding Information: This work was supported by the Canadian Institutes of Health Research (CIHR) (Grant MOP79525 , Grant GMH79044 and Postdoctoral Fellowship XWY93967 ).",

year = "2011",

month = feb,

day = "28",

doi = "10.1016/j.psychres.2010.07.009",

language = "English (US)",

volume = "185",

pages = "450--452",

journal = "Psychiatry Research",

issn = "0165-1781",

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TY - JOUR

T1 - Lack of association of NALCN genetic variants with schizophrenia

AU - Souza, Renan P.

AU - Rosa, Daniela V F

AU - Romano-Silva, Marco A.

AU - Zhen, Mei

AU - Meltzer, Herbert Y.

AU - Lieberman, Jeffrey A.

AU - Remington, Gary

AU - Kennedy, James L.

AU - Wong, Albert H C

N1 - Funding Information: This work was supported by the Canadian Institutes of Health Research (CIHR) (Grant MOP79525 , Grant GMH79044 and Postdoctoral Fellowship XWY93967 ).

PY - 2011/2/28

Y1 - 2011/2/28

N2 - NALCN (sodium leak channel, non-selective) is located on chromosome 13q (suggested linkage region for schizophrenia). We analyzed 21 polymorphisms in 464 schizophrenia subjects, 220 controls subjects and 119 small nuclear families. We observed nominal association with rs9518320 and rs9518331, suggesting that NALCN is not related to schizophrenia risk.

AB - NALCN (sodium leak channel, non-selective) is located on chromosome 13q (suggested linkage region for schizophrenia). We analyzed 21 polymorphisms in 464 schizophrenia subjects, 220 controls subjects and 119 small nuclear families. We observed nominal association with rs9518320 and rs9518331, suggesting that NALCN is not related to schizophrenia risk.

KW - Genetic association

KW - NALCN

KW - Schizophrenia

KW - VGCNL

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U2 - 10.1016/j.psychres.2010.07.009

DO - 10.1016/j.psychres.2010.07.009

M3 - Article

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AN - SCOPUS:79251594640

SN - 0165-1781

VL - 185

SP - 450

EP - 452

JO - Psychiatry Research

JF - Psychiatry Research

IS - 3

ER -

Lack of association of NALCN genetic variants with schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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