Lack of correlation between hsp-27 expression and tumor grade or nodal status in infiltrating ductal carcinoma of the breast

F. K. Storm*, S. Tomic, K. W. Gilchrist, D. M. Heisey, D. M. Mahvi

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Hsp-27 overexpression has been associated with reduced disease-free survival in early stage breast cancer. We postulated that invasive breast cancers with higher histologic grades or those demonstrating lymph node metastasis might overexpress this protein. Original H and E slides and paraffin blocks of primary infiltrating ductal carcinoma from 48 patients (T1-2, N∅, N1, M∅) were retrieved. Nineteen (40%) patients had negative nodes and 29 (60%) had positive nodes. Histologic grade (modified Scarff- Bloom-Richardson), lymph nodal status, and hsp-27 expression (by immunohistochemistry) were studied. Hsp-27 expression was not associated with either grade or lymph nodal status, supporting the contention that hsp-27 is an independent prognosticator of outcome.

Original languageEnglish (US)
Pages (from-to)177-179
Number of pages3
JournalRegional Cancer Treatment
Volume8
Issue number3-4
StatePublished - Dec 1 1995

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Carcinoma, Ductal, Breast
Lymph
Breast Neoplasms
Ductal Carcinoma
Paraffin
Disease-Free Survival
Neoplasms
Lymph Nodes
Immunohistochemistry
Neoplasm Metastasis
Proteins

Keywords

  • Breast cancer
  • Heat shock protein-27
  • Hsp-27
  • Nodal status
  • Tumor grade

ASJC Scopus subject areas

  • Oncology
  • Pharmacology

Cite this

Storm, F. K., Tomic, S., Gilchrist, K. W., Heisey, D. M., & Mahvi, D. M. (1995). Lack of correlation between hsp-27 expression and tumor grade or nodal status in infiltrating ductal carcinoma of the breast. Regional Cancer Treatment, 8(3-4), 177-179.
Storm, F. K. ; Tomic, S. ; Gilchrist, K. W. ; Heisey, D. M. ; Mahvi, D. M. / Lack of correlation between hsp-27 expression and tumor grade or nodal status in infiltrating ductal carcinoma of the breast. In: Regional Cancer Treatment. 1995 ; Vol. 8, No. 3-4. pp. 177-179.
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Storm, FK, Tomic, S, Gilchrist, KW, Heisey, DM & Mahvi, DM 1995, 'Lack of correlation between hsp-27 expression and tumor grade or nodal status in infiltrating ductal carcinoma of the breast', Regional Cancer Treatment, vol. 8, no. 3-4, pp. 177-179.

Lack of correlation between hsp-27 expression and tumor grade or nodal status in infiltrating ductal carcinoma of the breast. / Storm, F. K.; Tomic, S.; Gilchrist, K. W.; Heisey, D. M.; Mahvi, D. M.

In: Regional Cancer Treatment, Vol. 8, No. 3-4, 01.12.1995, p. 177-179.

Research output: Contribution to journalArticle

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T1 - Lack of correlation between hsp-27 expression and tumor grade or nodal status in infiltrating ductal carcinoma of the breast

AU - Storm, F. K.

AU - Tomic, S.

AU - Gilchrist, K. W.

AU - Heisey, D. M.

AU - Mahvi, D. M.

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AB - Hsp-27 overexpression has been associated with reduced disease-free survival in early stage breast cancer. We postulated that invasive breast cancers with higher histologic grades or those demonstrating lymph node metastasis might overexpress this protein. Original H and E slides and paraffin blocks of primary infiltrating ductal carcinoma from 48 patients (T1-2, N∅, N1, M∅) were retrieved. Nineteen (40%) patients had negative nodes and 29 (60%) had positive nodes. Histologic grade (modified Scarff- Bloom-Richardson), lymph nodal status, and hsp-27 expression (by immunohistochemistry) were studied. Hsp-27 expression was not associated with either grade or lymph nodal status, supporting the contention that hsp-27 is an independent prognosticator of outcome.

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