Lack of covalent binding of peroxisome proliferators nafenopin and WY-14 643 to DNA in vivo and in vitro

Sudhir K. Goel, Narendra D. Lalwani, William E. Fahl, Janardan K. Reddy*

*Corresponding author for this work

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

[3H][2-methyl-2-p-(1,2,3,4-tetrahydro-naphthyl)phenoxy] propionic acid (nafenopin), a hepatocarcinogenic peroxisome proliferator, when administered p.o. to normal intact and partially hepatectomized male F344 rats did not show any significant binding to DNA and RNA, but bound to proteins. The in vitro incubation of [3H]nafenopin and [3H]4-chloro-[6-(2,3-xylidino)pyrimidinylthio]acetic acid (Wy-14643), another peroxisome proliferator, with hepatic microsomes and calf thymus DNA also showed no significant binding of these chemicals to DNA.

Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
JournalToxicology Letters
Volume24
Issue number1
DOIs
StatePublished - Jan 1985

Keywords

  • Hepatocarcinogenesis
  • lipid peroxidation)
  • microsomes
  • non-mutagenic chemical carcinogens
  • oxidative stress
  • ß-oxidation HO

ASJC Scopus subject areas

  • Toxicology

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