Lack of effect of tricyclic antidepressants on serum prolactin levels

Herbert Y. Meltzer*, Songkait Piyakalmala, Paul Schyve, Victor S. Fang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


A previous report indicated that the tricyclic antidepressants imipramine and amitriptyline markedly increased plasma prolactin levels in man. We found no increases after acute or chronic treatment with either drug in usual clinical doses. The results indicate that blockade of serotonin reuptake does not affect basal prolactin levels in man.

Original languageEnglish (US)
Pages (from-to)185-187
Number of pages3
Issue number2
StatePublished - Jan 1 1977


  • Amitriptyline
  • Imipramine
  • Prolactin
  • Tricyclic antidepressants

ASJC Scopus subject areas

  • Pharmacology


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