Lack of heritability in ovarian germ cell malignancies

L. P. Shulman*, D. Muram, N. Marina, C. Jones, J. C. Portera, S. S. Wachtel, J. L. Simpson, S. Elias

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

OBJECTIVE: Our purpose was to determine whether relatives of patients with ovarian germ cell malignancies not associated with sex chromosome abnormalities are at increased risk for similar tumors. STUDY DESIGN: We reviewed pedigrees of 78 presumptive 46,XX patients (ages ranging from newborn to 20 years) with malignant ovarian germ cell tumors, excluding cases of dysgerminoma and gonadoblastoma. A three-generation family history of each proband was reviewed specifically to identify cancer in any family member. RESULTS: Seventy-eight mothers, 87 sisters, 135 aunts, and 156 grandmothers were surveyed. None had a malignant ovarian germ cell neoplasm or other malignant ovarian neoplasm. CONCLUSION: First- and second-degree relatives of probands with ovarian germ cell malignancies do not have an increased risk for similar tumors. These findings were not predicted because of the well-recognized association of hereditary tumors and early age of onset. (AM J Obstet Gynecol 1994;170:1803-8.)

Original languageEnglish (US)
Pages (from-to)1803-1808
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Volume170
Issue number6
DOIs
StatePublished - 1994

Keywords

  • Heritability
  • ovarian germ cell malignancies

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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