Lack of increase in vancomycin resistance of pediatric methicillin- resistant staphylococcus aureus isolates from 2000 to 2007

Xiaotian Zheng*, Chao Qi, Mollyn Arrieta, Amanda O'Leary, Deli Wang, Stanford T. Shulman

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We retrospectively studied 306 pediatric methicillin-resistant Staphylococcus aureus isolates collected in 2000/2001, 2003, 2005, and 2007 for possible vancomycin minimum inhibitory concentration (MIC) change over time using Etest, agar dilution, and broth microdilution (MicroScan) methods. Vancomycin MICs did not increase. Inducible clindamycin resistance declined significantly (53%-0%, P < 0.001). Considerably different proportions of isolates with vancomycin MIC = 2 μg/mL were identified by different laboratory methodologies, suggesting the need for caution in their interpretation and in comparing published data. During this period the proportion of USA300 strains increased dramatically.

Original languageEnglish (US)
Pages (from-to)882-884
Number of pages3
JournalPediatric Infectious Disease Journal
Volume29
Issue number9
DOIs
StatePublished - Sep 2010

Keywords

  • D-zone test
  • MRSA
  • inducible clindamycin resistance
  • pediatric
  • vancomycin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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