Lack of increase in vancomycin resistance of pediatric methicillin- resistant staphylococcus aureus isolates from 2000 to 2007

Xiaotian Zheng; Chao Qi; Mollyn Arrieta; Amanda O'Leary; Deli Wang; Stanford T. Shulman

doi:10.1097/INF.0b013e3181e284a6

Lack of increase in vancomycin resistance of pediatric methicillin- resistant staphylococcus aureus isolates from 2000 to 2007

Xiaotian Zheng^*, Chao Qi, Mollyn Arrieta, Amanda O'Leary, Deli Wang, Stanford T. Shulman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We retrospectively studied 306 pediatric methicillin-resistant Staphylococcus aureus isolates collected in 2000/2001, 2003, 2005, and 2007 for possible vancomycin minimum inhibitory concentration (MIC) change over time using Etest, agar dilution, and broth microdilution (MicroScan) methods. Vancomycin MICs did not increase. Inducible clindamycin resistance declined significantly (53%-0%, P < 0.001). Considerably different proportions of isolates with vancomycin MIC = 2 μg/mL were identified by different laboratory methodologies, suggesting the need for caution in their interpretation and in comparing published data. During this period the proportion of USA300 strains increased dramatically.

Original language	English (US)
Pages (from-to)	882-884
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	29
Issue number	9
DOIs	https://doi.org/10.1097/INF.0b013e3181e284a6
State	Published - Sep 2010

Keywords

D-zone test
MRSA
inducible clindamycin resistance
pediatric
vancomycin

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pediatrics, Perinatology, and Child Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/INF.0b013e3181e284a6

Cite this

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title = "Lack of increase in vancomycin resistance of pediatric methicillin- resistant staphylococcus aureus isolates from 2000 to 2007",

abstract = "We retrospectively studied 306 pediatric methicillin-resistant Staphylococcus aureus isolates collected in 2000/2001, 2003, 2005, and 2007 for possible vancomycin minimum inhibitory concentration (MIC) change over time using Etest, agar dilution, and broth microdilution (MicroScan) methods. Vancomycin MICs did not increase. Inducible clindamycin resistance declined significantly (53%-0%, P < 0.001). Considerably different proportions of isolates with vancomycin MIC = 2 μg/mL were identified by different laboratory methodologies, suggesting the need for caution in their interpretation and in comparing published data. During this period the proportion of USA300 strains increased dramatically.",

keywords = "D-zone test, MRSA, inducible clindamycin resistance, pediatric, vancomycin",

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AU - Zheng, Xiaotian

AU - Qi, Chao

AU - Arrieta, Mollyn

AU - O'Leary, Amanda

AU - Wang, Deli

AU - Shulman, Stanford T.

PY - 2010/9

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KW - D-zone test

KW - MRSA

KW - inducible clindamycin resistance

KW - pediatric

KW - vancomycin

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Lack of increase in vancomycin resistance of pediatric methicillin- resistant staphylococcus aureus isolates from 2000 to 2007

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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