Abstract
Objective: To investigate the association of lactation intensity and duration with postpartum diabetes and prediabetes risks among Chinese women with a history of gestational diabetes (GDM). Methods: We included 1260 women with a history of GDM who participated in the whole population's GDM universal screening survey by using the 1999 World Health Organization's criteria. Lactation intensity and lactation duration were collected by a standardized questionnaire. Postpartum diabetes and prediabetes risk were confirmed by an oral glucose tolerance test. Results: During a mean postpartum period of 3.65 years, we identified 114 cases of diabetes and 417 cases of prediabetes. The multivariable-adjusted hazard ratios based on different lactation intensity (exclusive formula, mixed feeding, and exclusive lactation) were 1.00, 0.68, 0.45 for diabetes (Ptrend = 0.008), and 1.00, 0.74, and 0.61 for prediabetes (Ptrend = 0.006), respectively. The multivariable-adjusted hazard ratios associated with different lactation duration (none, 0-6 months, 6-12 months, 12-18 months, and ≥18 months) were 1.00, 0.66, 0.42, 0.66, and 0.25 for diabetes (Ptrend = 0.013), and 1.00, 0.82, 0.62, 0.67, and 0.63 for prediabetes (Ptrend = 0.021), respectively. A restricted cubic spline curve showed a graded inverse association of lactation duration with the risks of diabetes and prediabetes (Ptrend < 0.001). Conclusions: Higher-lactation intensity and longer-lactation duration were significantly associated with lower risks of postpartum diabetes and prediabetes among Chinese women with a history of GDM.
| Original language | English (US) |
|---|---|
| Article number | e3115 |
| Journal | Diabetes/Metabolism Research and Reviews |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2019 |
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Keywords
- diabetes
- gestational diabetes
- lactation
- prediabetes
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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Lactation intensity and duration to postpartum diabetes and prediabetes risk in women with gestational diabetes. / Shen, Yun; Leng, Junhong; Li, Weiqin; Zhang, Shuang; Liu, Huikun; Shao, Ping; Wang, Peng; Wang, Leishen; Tian, Huiguang; Zhang, Cuilin; Yang, Xilin; Yu, Zhijie; Hou, Lifang; Tuomilehto, Jaakko; Hu, Gang.
In: Diabetes/Metabolism Research and Reviews, Vol. 35, No. 3, e3115, 03.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Lactation intensity and duration to postpartum diabetes and prediabetes risk in women with gestational diabetes
AU - Shen, Yun
AU - Leng, Junhong
AU - Li, Weiqin
AU - Zhang, Shuang
AU - Liu, Huikun
AU - Shao, Ping
AU - Wang, Peng
AU - Wang, Leishen
AU - Tian, Huiguang
AU - Zhang, Cuilin
AU - Yang, Xilin
AU - Yu, Zhijie
AU - Hou, Lifang
AU - Tuomilehto, Jaakko
AU - Hu, Gang
PY - 2019/3
Y1 - 2019/3
N2 - Objective: To investigate the association of lactation intensity and duration with postpartum diabetes and prediabetes risks among Chinese women with a history of gestational diabetes (GDM). Methods: We included 1260 women with a history of GDM who participated in the whole population's GDM universal screening survey by using the 1999 World Health Organization's criteria. Lactation intensity and lactation duration were collected by a standardized questionnaire. Postpartum diabetes and prediabetes risk were confirmed by an oral glucose tolerance test. Results: During a mean postpartum period of 3.65 years, we identified 114 cases of diabetes and 417 cases of prediabetes. The multivariable-adjusted hazard ratios based on different lactation intensity (exclusive formula, mixed feeding, and exclusive lactation) were 1.00, 0.68, 0.45 for diabetes (Ptrend = 0.008), and 1.00, 0.74, and 0.61 for prediabetes (Ptrend = 0.006), respectively. The multivariable-adjusted hazard ratios associated with different lactation duration (none, 0-6 months, 6-12 months, 12-18 months, and ≥18 months) were 1.00, 0.66, 0.42, 0.66, and 0.25 for diabetes (Ptrend = 0.013), and 1.00, 0.82, 0.62, 0.67, and 0.63 for prediabetes (Ptrend = 0.021), respectively. A restricted cubic spline curve showed a graded inverse association of lactation duration with the risks of diabetes and prediabetes (Ptrend < 0.001). Conclusions: Higher-lactation intensity and longer-lactation duration were significantly associated with lower risks of postpartum diabetes and prediabetes among Chinese women with a history of GDM.
AB - Objective: To investigate the association of lactation intensity and duration with postpartum diabetes and prediabetes risks among Chinese women with a history of gestational diabetes (GDM). Methods: We included 1260 women with a history of GDM who participated in the whole population's GDM universal screening survey by using the 1999 World Health Organization's criteria. Lactation intensity and lactation duration were collected by a standardized questionnaire. Postpartum diabetes and prediabetes risk were confirmed by an oral glucose tolerance test. Results: During a mean postpartum period of 3.65 years, we identified 114 cases of diabetes and 417 cases of prediabetes. The multivariable-adjusted hazard ratios based on different lactation intensity (exclusive formula, mixed feeding, and exclusive lactation) were 1.00, 0.68, 0.45 for diabetes (Ptrend = 0.008), and 1.00, 0.74, and 0.61 for prediabetes (Ptrend = 0.006), respectively. The multivariable-adjusted hazard ratios associated with different lactation duration (none, 0-6 months, 6-12 months, 12-18 months, and ≥18 months) were 1.00, 0.66, 0.42, 0.66, and 0.25 for diabetes (Ptrend = 0.013), and 1.00, 0.82, 0.62, 0.67, and 0.63 for prediabetes (Ptrend = 0.021), respectively. A restricted cubic spline curve showed a graded inverse association of lactation duration with the risks of diabetes and prediabetes (Ptrend < 0.001). Conclusions: Higher-lactation intensity and longer-lactation duration were significantly associated with lower risks of postpartum diabetes and prediabetes among Chinese women with a history of GDM.
KW - diabetes
KW - gestational diabetes
KW - lactation
KW - prediabetes
UR - http://www.scopus.com/inward/record.url?scp=85059860458&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059860458&partnerID=8YFLogxK
U2 - 10.1002/dmrr.3115
DO - 10.1002/dmrr.3115
M3 - Article
C2 - 30548991
AN - SCOPUS:85059860458
VL - 35
JO - Diabetes/Metabolism Research and Reviews
JF - Diabetes/Metabolism Research and Reviews
SN - 1520-7552
IS - 3
M1 - e3115
ER -