Lamin dynamics

Robert D. Moir*, Robert Goldman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Nuclear lamins for a highly insoluble structure, the nuclear lamina, which is associated with the nuclear envelope. Recent results suggest, however, that the lamins are more dynamic than originally thought. They accumulate in nucleoplasmic foci in the G1 stage of the cell cycle and later appear mainly in the peripheral lamina. Some of the lamin foci are closely associated with heterochromatin. Furthermore, the various lamin types assemble into the lamina polymer independently of each other. Both the assembly and disassembly of the lamins, as well as the interaction of the lamins with other nuclear structures such as the nuclear membrane, may be mediated by phosphorylation and dephosphorylation.

Original languageEnglish (US)
Pages (from-to)408-411
Number of pages4
JournalCurrent Opinion in Cell Biology
Volume5
Issue number3
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Cell Biology

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