TY - JOUR
T1 - Lamin dynamics
AU - Moir, Robert D.
AU - Goldman, Robert
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Nuclear lamins for a highly insoluble structure, the nuclear lamina, which is associated with the nuclear envelope. Recent results suggest, however, that the lamins are more dynamic than originally thought. They accumulate in nucleoplasmic foci in the G1 stage of the cell cycle and later appear mainly in the peripheral lamina. Some of the lamin foci are closely associated with heterochromatin. Furthermore, the various lamin types assemble into the lamina polymer independently of each other. Both the assembly and disassembly of the lamins, as well as the interaction of the lamins with other nuclear structures such as the nuclear membrane, may be mediated by phosphorylation and dephosphorylation.
AB - Nuclear lamins for a highly insoluble structure, the nuclear lamina, which is associated with the nuclear envelope. Recent results suggest, however, that the lamins are more dynamic than originally thought. They accumulate in nucleoplasmic foci in the G1 stage of the cell cycle and later appear mainly in the peripheral lamina. Some of the lamin foci are closely associated with heterochromatin. Furthermore, the various lamin types assemble into the lamina polymer independently of each other. Both the assembly and disassembly of the lamins, as well as the interaction of the lamins with other nuclear structures such as the nuclear membrane, may be mediated by phosphorylation and dephosphorylation.
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U2 - 10.1016/0955-0674(93)90004-A
DO - 10.1016/0955-0674(93)90004-A
M3 - Article
C2 - 8352956
AN - SCOPUS:0027614209
SN - 0955-0674
VL - 5
SP - 408
EP - 411
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 3
ER -